AB5642P | Anti-Cannabinoid Receptor 2 Antibody, CT

AB5642P
50 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RELISA, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5642P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cannabinoid Receptor 2 Antibody, CT
      Alternate Names
      • CB2
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.4, containing 0.1% BSA.
      Applications
      ApplicationDetect Cannabinoid Receptor 2 using this Anti-Cannabinoid Receptor 2 Antibody, C-terminus validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL using ECL.

      ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide (Catalog Number AG214) per well.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenAn 18 amino acid peptide sequence near the cytoplasmic, C-terminus of rat CB2 (Munro et al. 1993; Shire et al. 1996; Griffin et al. 2000).
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes rat Cannabinoid Receptor 2 (CB2). The immunogen shows no significant sequence homology with CB1.

      SPECIES REACTIVITIES: The immunogen peptide is 88% conserved in mouse and 82% in human. Reactivity with other species has not been confirmed.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.
      Gene Symbol
      • CNR2
      • CB-2
      • OTTHUMP00000044841
      • CB2
      • CX5
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P34972 # Involved in cannabinoid-induced CNS effects through G- protein mediated inhibition of adenylate cyclase. Could be a receptor for anandamide.
      SIZE: 360 amino acids; 39681 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Not found in brain. Found in spleen.
      SIMILARITY: SwissProt: P34972 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-CANNABINOID RECEPTOR 2 (CB2) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2148211 2148211
      RABBIT ANTI-CANNABINOID RECEPTOR 2 (CB2) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2370569 2370569
      RABBIT ANTI-CANNABINOID RECEPTOR 2 (CB2) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2392194 2392194
      RABBIT ANTI-CANNABINOID RECEPTOR 2 (CB2) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2439649 2439649
      RABBIT ANTI-CANNABINOID RECEPTOR 2 (CB2) -2634653 2634653
      RABBIT ANTI-CANNABINOID RECEPTOR 2 (CB2) -2649235 2649235
      RABBIT ANTI-CANNABINOID RECEPTOR 2 (CB2) -2884802 2884802
      RABBIT ANTI-CANNABINOID RECEPTOR 2 (CB2) AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2197158 2197158

      References

      Reference overviewPub Med ID
      Cannabinoids modulate Olig2 and polysialylated neural cell adhesion molecule expression in the subventricular zone of post-natal rats through cannabinoid receptor 1 and cannabinoid receptor 2.
      Angel Arévalo-Martín,Daniel García-Ovejero,Ana Rubio-Araiz,Oscar Gómez,Francisco Molina-Holgado,Eduardo Molina-Holgado
      The European journal of neuroscience  26  2007

      Show Abstract
      17880390 17880390

      Data Sheet

      Title
      Anti-Cannabinoid Receptor 2, C-terminus - Data Sheet