MABN226 | Anti-DENR Antibody, clone 10D9.1

MABN226
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN226
      DescriptionAnti-DENR Antibody, clone 10D9.1
      Alternate Names
      • Density-regulated protein
      • DRP
      • Protein DRP1
      • Smooth muscle cell-associated protein 3
      • SMAP-3
      Background InformationThe protein named density-regulated protein (DRP1), also known as DRP, or Protein DRP1 or Smooth muscle cell-associated protein 3 (SMAP-3), and encoded by the gene DENR/DRP1, is an important translational control protein that appears to function by scanning target mRNAs for the recognition codon when complexed with the translational initiation complex. DRP1 also modulates the translation of particular cancer-related mRNAs when recruited to the translational complex by the oncogene MCTS1 and DRP1 is up regulated in many cancers such as ovarian and breast cancers. Additionally, DRP1’s expression is regulated by increasing cell density through interaction with heterogeneous nuclear ribonucleoprotein D (HNRNPD) protein, a critical protein that complexes with heterogeneous nuclear RNA and pre-mRNAs and fosters mRNA stability. Density-regulated protein (DRP1) is localized to the in heart, skeletal muscle, brain, placenta, liver and pancreas, with weaker expression seen in lung and kidney.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-DENR Antibody, clone 10D9.1 is a mouse monoclonal antibody, validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected DENR in human cerebral cortex and human cardiac myocytes tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of human DENR.
      EpitopeC-terminus
      Clone10D9.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DENR
      • DRP1
      • H14
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~22 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PC-12 cell lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected DENR in 10 µg of PC-12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications