MABT467 | Anti-DSG2, clone EPR6767(B), Rabbit Monoclonal Antibody

MABT467
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, FCRbUnpurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT467
      DescriptionAnti-DSG2, clone EPR6767(B), Rabbit Monoclonal Antibody
      Alternate Names
      • Desmoglein-2
      • Cadherin family member 5
      • HDGC
      Background InformationDesmoglein-2 (DSG2) is a single-pass type I membrane protein. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmosomal cadherins, consisting of four desmogleins (DSG1-4) and three desmocollins (DSC1-3) in humans, mediate adhesion through calcium-dependent homophilic/heterophilic interactions. DSG2 is widely expressed in epithelial and non-epithelial tissues such as the intestine, epidermis, testis, and heart. Mutations in DSG2 have been assoicated with familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10) and cardiomyopathy dilated type 1BB (CMD1BB).
      References
      Product Information
      FormatUnpurified
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: A 1:10-100 dilution from a representative lot detected DSG2 in T47-D cells.

      Produced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to the extracellular domain of human DSG2.
      Epitopeextracellular domain
      CloneEPR6767(B)
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • DSG2
      • CDHF5
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~160 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SKBR-3, HepG2, HEK293T, A431, HeLa, and T47-D cell lysates.

      Western Blotting Analysis: A 1:50,000-200,000 dilution of this antibody detected DSG2 in SKBR-3, HepG2, HEK293T, A431, HeLa, and T47-D cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies