AB2040 | Anti-Fibronectin Antibody

AB2040
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RELISA, RIA, IHCRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2040
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Fibronectin Antibody
      References
      Product Information
      FormatPurified
      PresentationIgG fraction. No preservatives. Liquid containing 0.01M Phosphate, 0.09M NaCl, pH7.2.
      Applications
      ApplicationAnti-Fibronectin Antibody is an antibody against Fibronectin for use in ELISA, RIA, IH.
      Key Applications
      • ELISA
      • Radioimmunoassay
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:80 dilution for immunofluorescent staining of frozen rat skin and liver tissues.

      Radioimmunoassay

      ELISA

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenFibronectin extracted and purified from rat plasma.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityAntibody shows less than 0.1% reactivity with rat Collagen Types I, II, III, V and rat Elastin by radioimmunoassay.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
      Gene Symbol
      • FN1
      • DKFZp686O13149
      • DKFZp686H0342
      • DKFZp686I1370
      • MSF
      • FN
      • CIG
      • DKFZp686F10164
      • LETS
      • FINC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P02751 # Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).
      SIZE: 2386 amino acids; 262607 Da
      SUBUNIT: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
      TISSUE SPECIFICITY: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.DEVELOPMENTAL STAGE: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
      PTM: Sulfated.
      SIMILARITY: SwissProt: P02751 ## Contains 12 fibronectin type-I domains. & Contains 2 fibronectin type-II domains. & Contains 16 fibronectin type-III domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI- RAT FIBRONECTIN - 2565752 2565752
      RABBIT ANTI- RAT FIBRONECTIN -2681226 2681226
      RABBIT ANTI- RAT FIBRONECTIN -2797784 2797784
      RABBIT ANTI- RAT FIBRONECTIN -2892564 2892564
      RABBIT ANTI- RAT FIBRONECTIN POLYCLONAL ANTIBODY - 2300447 2300447

      References

      Reference overviewApplicationPub Med ID
      Long-term characterization of axon regeneration and matrix changes using multiple channel bridges for spinal cord regeneration.
      Tuinstra, HM; Margul, DJ; Goodman, AG; Boehler, RM; Holland, SJ; Zelivyanskaya, ML; Cummings, BJ; Anderson, AJ; Shea, LD
      Tissue engineering. Part A  20  1027-37  2014

      Show Abstract
      Immunofluorescence24168314 24168314
      Phage-based molecular probes that discriminate force-induced structural states of fibronectin in vivo.
      Cao, L; Zeller, MK; Fiore, VF; Strane, P; Bermudez, H; Barker, TH
      Proceedings of the National Academy of Sciences of the United States of America  109  7251-6  2012

      Show Abstract
      22529344 22529344
      Development of an esophagus acellular matrix tissue scaffold.
      Amit D Bhrany, Benjamin L Beckstead, Tess C Lang, D Gregory Farwell, Cecilia M Giachelli, Buddy D Ratner
      Tissue engineering  12  319-30  2006

      Show Abstract
      16548690 16548690

      Data Sheet

      Title
      Anti-Fibronectin - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies