07-178 | Anti-Hox A9 Antibody

07-178
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MEMSA, WB, ICCRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-178
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Hox A9 Antibody
      Background InformationHOXA9 is a transcription factor with a central role in both haemopoiesis and leukaemia. High levels of HOXA9 expression in haemopoietic cells is a characteristic feature of acute myeloid leukaemia (AML), and may be sufficient to cause this disease. Overexpression of Hoxa-9 markedly expands hematopoietic stem cells. HOXA9 expression changes dramatically with age - a uniformly low level of expression during early adulthood is replaced by a frequently very high expression in adults over sixty.
      References
      Product Information
      FormatPurified
      Control
      • Hoxa9 immortalized HF1 cells
      PresentationProtein A purified immunoglobulin presented in 0.02M phosphate buffer, pH 7.6, 0.25M NaCl, and 0.1% Sodium Azide before the addition of glycerol to 30%.
      Applications
      ApplicationDetect Hox A9 with Anti-Hox A9 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in EMSA, WB, ICC.
      Key Applications
      • Electrophoretic Mobility Shift Assay
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      ImmunogenGST fusion protein corresponding to residues 194-272 of mouse Hox A9
      HostRabbit
      SpecificityHox A9
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteBased on a BLAST search, the antibody will likely cross react with Newt, Coelacanth, Dog, Chicken, and Rat Hox A9; Antelope, Mouse and Guinea Pig Hox 1.7; Frog, human and Zebrafish Hox A-9B; and Kenyan Clawed Frog Hox B.1
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryIn vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis.
      Gene Symbol
      • HOXA9
      • MGC1934
      • Hox-1G
      • HOX1.7
      • HOX1G
      • HOX1
      • ABD-B
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P31269 # Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
      SIZE: 272 amino acids; 30172 Da
      SUBCELLULAR LOCATION: Nucleus.
      DISEASE: SwissProt: P31269 # A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98. & A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2.
      SIMILARITY: SwissProt: P31269 ## Belongs to the Abd-B homeobox family. & Contains 1 homeobox DNA-binding domain.
      Molecular Weight36kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot on whole cell lysates of Hoxa9 immortalized HF1 myeloid progenitor cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Hox A9 2475737
      Anti-Hox A9 (rabbit polyclonal IgG) - 2123712 2123712
      Anti-Hox A9 (rabbit polyclonal IgG) - 2387521 2387521
      Anti-Hox A9 (rabbit polyclonal IgG) - 2005585 2005585
      Anti-Hox A9 (rabbit polyclonal IgG) - 2193156 2193156
      Anti-Hox A9 (rabbit polyclonal IgG) - 2295658 2295658
      Anti-Hox A9 - 0609039658 0609039658
      Anti-Hox A9 - 1962112 1962112
      Anti-Hox A9 - 20333 20333
      Anti-Hox A9 - 33450 33450

      References

      Reference overviewApplicationPub Med ID
      Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.
      Park, SM; Gönen, M; Vu, L; Minuesa, G; Tivnan, P; Barlowe, TS; Taggart, J; Lu, Y; Deering, RP; Hacohen, N; Figueroa, ME; Paietta, E; Fernandez, HF; Tallman, MS; Melnick, A; Levine, R; Leslie, C; Lengner, CJ; Kharas, MG
      The Journal of clinical investigation  125  1286-98  2015

      Show Abstract
      25664853 25664853
      Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.
      Beachy, SH; Onozawa, M; Silverman, D; Chung, YJ; Rivera, MM; Aplan, PD
      Experimental hematology  41  518-529.e5  2013

      Show Abstract
      Western Blotting23435313 23435313
      Immune mediators regulate CFTR expression through a bifunctional airway-selective enhancer.
      Zhang, Z; Leir, SH; Harris, A
      Molecular and cellular biology  33  2843-53  2013

      Show Abstract
      23689137 23689137
      An MLL-dependent network sustains hematopoiesis.
      Artinger, Erika L, et al.
      Proc. Natl. Acad. Sci. U.S.A., (2013)  2013

      Show Abstract
      23744037 23744037
      Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.
      Geng, H; Brennan, S; Milne, TA; Chen, WY; Li, Y; Hurtz, C; Kweon, SM; Zickl, L; Shojaee, S; Neuberg, D; Huang, C; Biswas, D; Xin, Y; Racevskis, J; Ketterling, RP; Luger, SM; Lazarus, H; Tallman, MS; Rowe, JM; Litzow, MR; Guzman, ML; Allis, CD; Roeder, RG; Müschen, M; Paietta, E; Elemento, O; Melnick, AM
      Cancer discovery  2  1004-23  2012

      Show Abstract
      Western Blotting23107779 23107779
      Smad4 binds Hoxa9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by Hoxa9 and leukemia transformation.
      Quéré, R; Karlsson, G; Hertwig, F; Rissler, M; Lindqvist, B; Fioretos, T; Vandenberghe, P; Slovak, ML; Cammenga, J; Karlsson, S
      Blood  117  5918-30  2011

      Show Abstract
      21471525 21471525
      Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.
      A Gessner,M Thomas,P Garrido Castro,L Büchler,A Scholz,T H Brümmendorf,N Martinez Soria,J Vormoor,J Greil,O Heidenreich
      Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K  24  2010

      Show Abstract
      20686504 20686504
      Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.
      Wang, GG; Song, J; Wang, Z; Dormann, HL; Casadio, F; Li, H; Luo, JL; Patel, DJ; Allis, CD
      Nature  459  847-51  2009

      Show Abstract
      Immunofluorescence19430464 19430464
      HOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis.
      Yu-Long Hu, Steve Fong, Christina Ferrell, Corey Largman, Wei-Fang Shen, YL Hu, S Fong, C Ferrell, C Largman, WF Shen
      Molecular and cellular biology  29  5181-92  2009

      Show Abstract Full Text Article
      19620287 19620287
      Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis.
      Waning, DL; Li, B; Jia, N; Naaldijk, Y; Goebel, WS; HogenEsch, H; Chun, KT
      Blood  112  320-9  2008

      Show Abstract
      18339895 18339895