MABF328 | Anti-IL-10 (human) Antibody, PE, clone JES3-19F1

MABF328
100 tests  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCRPEMonoclonal Antibody
      Description
      Catalogue NumberMABF328
      DescriptionAnti-IL-10 (human) Antibody, PE, clone JES3-19F1
      Alternate Names
      • Interleukin-10
      • IL-10
      • Cytokine synthesis inhibitory factor
      • CSIF
      Background InformationInterleukin-10 (IL-10), originally known as Cytokine Synthesis Inhibitory Factor (CSIF) is a protein that shares over 80% sequence homology with the Epstein-Barr Virus protein BCRFI. IL-10 down regulates the expression of Th1 cytokines, major histocompatibility complex class II antigens, and costimulatory molecules on macrophages. It also enhaces B cell survival, proliferation, and antibody production. IL-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. IL-10 is produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types. A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease (GVHDS), a major complication of allogeneic bone marrow transplantation, in which mature donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease. Knockout studies suggest that IL-10 is an immunoregulator in the intestinal tract.
      References
      Product Information
      FormatPE
      PresentationPurified rat conjugate antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide and 0.2% (w/v) BSA.
      Applications
      ApplicationAnti-IL-10 (human) Antibody, PE, clone JES3-19F1 is a highly specific rat monoclonal antibody & that targets IL-10 & has been tested in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenCOS-expressed recombinant human IL-10
      CloneJES3-19F1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • IL10
      Purification MethodAffinity
      UniProt Number
      Molecular Weight21 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThe antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

      Flow Cytometry Analysis: 20 μL of this antibody detected IL-10 in one million LPS-stimulated human peripheral blood monocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications