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05-1108-KC | Anti-Insulin, clone MAB1 (1mg) KC

05-1108-KC
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      Overview

      Replacement Information
      Description
      Catalogue Number05-1108-KC
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Insulin, clone MAB1 (1mg) KC
      OverviewThis product is intended for use by IVD manufacturers.
      Contact customer service for assistance: oem.reagents@emdmillipore.com
      Alternate Names
      • Anti-Insulin
      Background InformationInsulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human pancreas tissue.
      PresentationThe monoclonal is presented as 1mg in 1ml phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Applications
      ApplicationAnti-Insulin Antibody, clone1 is an antibody against Insulin for use in IH(P).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenBiosynthetic human insulin
      CloneMAB1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes an epitope including the amino acid B30.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ILPR
      • IRDN
      • OTTHUMP00000011161
      • OTTHUMP00000011162
      • OTTHUMP00000196038
      • insulin
      • proinsulin
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      SUBUNIT STRUCTURE: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
      SUBCELLULAR LOCATION: Secreted.
      INVOLVEMENT IN DISEASE: Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
      PHARMACEUTICAL USE: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.
      SEQUENCE SIMILARITIES: Belongs to the insulin family.
      SEQUENCE CAUTION: The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
      Molecular WeightApprox. 12 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human pancreas tissue.
      Immunohistochemistry Analysis: 1.25 µg/mL of this antibody detected insulin in human pancreas tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2-8°C and use within 1 year from date of receipt.
      Packaging Information
      Material SizeBulk packaging. Please inquire.
      Transport Information
      Supplemental Information
      Specifications

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      Catalogue Number Description  
      05-1108 Anti-Insulin Antibody, clone1 Show Pricing & Availability

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      Categories

      IVD/OEM Materials & Reagents > Bulk & Custom Antibodies > Primary Bulk Antibodies by Target > Metabolic Diseases, Diabetes related
      Life Science Research > Antibodies and Assays > Primary Antibodies