MAB1959-AF488 | Anti-Integrin ß1 Antibody, clone P5D2, Alexa Fluor® 488 Conjugate

MAB1959-AF488
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IHCMAlexaFluor®488Monoclonal Antibody
      Description
      Catalogue NumberMAB1959-AF488
      DescriptionAnti-Integrin ß1 Antibody, clone P5D2, Alexa Fluor® 488 Conjugate
      Alternate Names
      • Integrin beta-1
      • CD29
      • Glycoprotein Iia
      • GPIIA
      • Integrin VLA-4 subunit beta
      • Very late activation protein
      • beta polypeptide
      Background InformationIntegrin beta-1 (UniProt P05556; also known as CD29, Glycoprotein Iia, GPIIA, Integrin VLA-4 subunit beta, Very late activation protein, beta polypeptide) is encoded by the ITGB1 (also known as FNRB, MDF2, MSK12, VLA-BETA, VLAB) gene (Gene ID 3688) in human. Integrin beta-1 is a 130 kDa transmembrane glycoprotein that interact with various integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptor complexes that bind to specific extracellular matrix proteins. Integrin receptors regulate a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor growth and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to the activation of signal transduction pathways and regulation of gene expression.
      References
      Product Information
      FormatAlexaFluor®488
      PresentationPurified mouse monoclonal IgG2bκ antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
      Applications
      ApplicationThis Anti-Integrin ß1 Antibody, clone P5D2, Alexa Fluor® 488 Conjugate is validated for use in Flow Cytometry, Immunohistochemistry for the detection of Integrin ß1.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Integrin ß1 in human small intestine and rat testis tissues.
      Flow Cytometry Analysis: 1.0 µg of this antibody from a representative lot detected Integrin ß1 in 1X10E6 A431 cells.
      The unconjugated antibody (Cat. No. MAB1959) is shown to be suitable also for functional assay, ELISA, , flow cytometry, immunocytochemistry, immunohistochemistry, and immunoprecipitation applications.
      Biological Information
      ImmunogenHuman keratinocytes derived from skin.
      EpitopeExtracellular domain.
      CloneP5D2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityReacts with Integrin beta-1.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Mouse. Rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ITGB1
      • FNRB
      • MDF2
      • MSK12
      • VLA-BETA
      • VLAB
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular Weight~88 kDa observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in mouse cerebellum tissue.

      Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Integrin ß1 in mouse cerebellum tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation