MAB416 | Anti-Interferon-β Antibody, clone A1

MAB416
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB416
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Interferon-β Antibody, clone A1
      References
      Product Information
      FormatPurified
      PresentationImmunoglobulin purified by Protein A from culture supernatant. Liquid in 50 mM Tris-Glycine, pH 7.5 with no preservative.
      Applications
      ApplicationAnti-Interferon-β Antibody, clone A1 detects level of Interferon-β & has been published & validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesImmunoblotting

      ELISA

      Neutralization of IFN-beta bioactivity; 90% reduction of bioactivity at 1.4 μg/mL for recombinant IFN-beta and 2.7 μg/mL for natural IFN-beta. Assay method used is provided in Grossberg, S.E. et al, Manual of Clinical Immunology.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHuman interferon beta.
      CloneA1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityHuman interferon-beta (IFN-beta). Recognizes amino acids 30-47 of IFN-beta. No cross-reactivity with Human IFN-alpha or IFN-gamma.
      IsotypeIgGκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IL6
      • IL-6
      • HSF
      • BSF2
      • BSF-2
      • CDF
      • IFNB2
      • HGF
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05231 # IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
      SIZE: 212 amino acids; 23718 Da
      SUBCELLULAR LOCATION: Secreted.
      PTM: N- and O-glycosylated.
      DISEASE: SwissProt: P05231 # Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement. & At least 1 polymorphism in the IL6 gene renders HIV- infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.
      SIMILARITY: SwissProt: P05231 ## Belongs to the IL-6 superfamily.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to twelve months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN INTERFERON-BETA - 2524054 2524054
      MOUSE ANTI-HUMAN INTERFERON-BETA MONOCLONAL ANTIBODY - 2179308 2179308

      References

      Reference overviewPub Med ID
      Neutralizing antibodies to interferon beta in multiple sclerosis: analytical evaluation for validation of a cytopathic effect assay.
      Catherine Massart,Jacqueline Gibassier,Joël Oger,Emmanuelle Le Page,Gilles Edan
      Clinica chimica acta; international journal of clinical chemistry  377  2007

      Show Abstract
      17123498 17123498
      Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3.
      Susan E Sweeney,Ling Mo,Gary S Firestein
      Arthritis and rheumatism  56  2007

      Show Abstract
      17328045 17328045
      Reduced effectiveness of long-term interferon-beta treatment on relapses in neutralizing antibody-positive multiple sclerosis patients: a Canadian multiple sclerosis clinic-based study.
      C Boz,J Oger,E Gibbs,S E Grossberg,
      Multiple sclerosis (Houndmills, Basingstoke, England)  13  2007

      Show Abstract
      17967840 17967840
      Analysis of antigenic domains on natural and recombinant human IFN-beta by the inhibition of biologic activities with monoclonal antibodies.
      Redlich, P N and Grossberg, S E
      J. Immunol., 143: 1887-93 (1989)  1989

      Show Abstract
      2476486 2476486

      Data Sheet

      Title
      Anti-Interferon-beta, clone A1 - Data Sheet

      Related Products & Applications

      Related Products

      Catalogue Number Description  
      04-1095 Anti-IL-6 Antibody, clone E457, rabbit monoclonal Show Pricing & Availability
      AB1421 Anti-Interleukin-6 Antibody Show Pricing & Availability
      AB1423 Anti-Interleukin-6 Antibody Show Pricing & Availability
      AB1431 Anti-Interferon-β Antibody Show Pricing & Availability
      AB1839 Anti-Interleukin-6 Antibody Show Pricing & Availability
      CBL2117 Anti-Interleukin-6 Antibody, clone B-E8 Show Pricing & Availability
      MAB1004 Anti-Interleukin-6 Antibody, clone 4B6 Show Pricing & Availability
      MABF342 Anti-IL-6 (human) Antibody, FITC, clone MQ2-13A5 Show Pricing & Availability
      MABF41 Anti-Interleukin-6 (IL-6) Antibody, clone 1G3 Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies