ABS487 | Anti-LARS Antibody

ABS487
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS487
      DescriptionAnti-LARS Antibody
      Alternate Names
      • Leucine-tRNA ligase, cytoplasmic
      • Leucyl-tRNA synthetase
      • LeuRS
      Background InformationLARS is the critical cytoplasmic enzyme that charges the tRNA for leucine to become L-leucyl-tRNA, or tRNA(Leu). LARS is thus critical for protein biosynthesis and LARS is up regulated, like many proteins, in cancer. LARS is localized in the cytoplasm and regulated via acetylation. Interestingly, recent research demonstrates that LARS and other tRNA synthetases play key roles as amino acid cellular sensors in my cellular signaling pathways such as mTOR which regulate cell size, protein translation, and even autophagy.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-LARS Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of LARS.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected LARS in human kidney and human liver tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human LARS near the C-terminus.
      EpitopeNear C-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • LARS
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~140 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HUVEC cell lysate.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected LARS in 10 µg of HUVEC cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications