AB2267 | Anti-LCN2 Antibody

AB2267
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, B, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2267
      DescriptionAnti-LCN2 Antibody
      Alternate Names
      • lipocalin 2
      • migration-stimulating factor inhibitor
      • siderocalin
      • Oncogene 24p3
      • 25 kDa alpha-2-microglobulin-related subunit of MMP-9
      • lipocalin 2 (oncogene 24p3)
      • neutrophil gelatinase-associated lipocalin
      • Lipocalin-2
      Background InformationLCN2 (also known as Neurophil Gelatinase-Associated Lipocalin or NGAL) belongs to a superfamily of lipocalins, a collection of small, diversely functional, extracellular proteins. NGAL is secreted from neutrophil granules in three different forms; a monomer of 25 kDa, a disulfide-linked homodimer at 46 kDa, and a disulfide-linked heterodimer with MMP-9 at 135-kDa. It is widely known to induce development of kidney epithelia, to bind and traffic iron, and to act as a molecular signal under inflammatory conditions, such as Crohn’s Disease. Multiple carcinoma studies have also shown elevated expression levels of LCN2 in several different human tumors affecting such organs as: colon, lung, breast, ovaries and pancreas. Additionally, there has been great interest in this protein as a possible marker for: onset of Acute Kidney Injury following cardiac surgery, the progression of Chronic Kidney Disease (CKD), and the survival chances of patients with Chronic Heart Failure (CHF).
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human kidney tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationAnti-LCN2 Antibody detects level of LCN2 & has been published & validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:200 dilution of Anti-LCN2 antibody from a previous lot detected LCN2 in human spleen tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the mature chain of human LCN2.
      EpitopeMature chain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes LCN2.
      Species Reactivity
      • Human
      • Mouse
      • Bovine
      • Rat
      Species Reactivity NoteDemonstrated to react with human. Predicted to react with mouse, bovine, and rat based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NGAL
      • 24p3
      • p25
      • MSFI
      • HNL
      • LCN2
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Transport of small lipophilic substances Potential.

      SUBUNIT STRUCTURE: Forms a covalently linked, disulfide-bridged heterodimer with the 92 kDa type V collagenase (MMP-9).

      SUBCELLULAR LOCATION: Secreted.

      TISSUE SPECIFICITY: Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lungs. Not found in the small intestine or peripheral blood leukocytes.

      SEQUENCE SIMILARITIES: Belongs to the calycin superfamily. Lipocalin family.
      Molecular WeightLCN2 band observed at 25 kDa. Heavy concentration of tissue lysate and a 5 minute exposure time were used to generate the band of interest.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human kidney tissue lysate.

      Western Blot Analysis: 5 µg/mL of this antibody detected LCN2 in 10 µg of human kidney tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-LCN2 - 2145100 2145100
      Anti-LCN2 - 2424749 2424749
      Anti-LCN2 - 1952469 1952469
      Anti-LCN2 - 2030040 2030040
      Anti-LCN2 - 2211067 2211067
      Anti-LCN2 - 2344675 2344675
      Anti-LCN2 - NG1888897 NG1888897
      Anti-LCN2 - NG1928925 NG1928925
      Anti-LCN2 - NRG1736361 NRG1736361
      Anti-LCN2 -2500557 2500557

      References

      Reference overviewApplicationPub Med ID
      Reactive astrocytes secrete lcn2 to promote neuron death.
      Bi, F; Huang, C; Tong, J; Qiu, G; Huang, B; Wu, Q; Li, F; Xu, Z; Bowser, R; Xia, XG; Zhou, H
      Proceedings of the National Academy of Sciences of the United States of America  110  4069-74  2013

      Show Abstract
      Immunohistochemistry23431168 23431168

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies