ABD17 | Anti-LGR5 (GPR49) Antibody

ABD17
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABD17
      DescriptionAnti-LGR5 (GPR49) Antibody
      Alternate Names
      • Leucine-rich repeat-containing G-protein coupled receptor 5
      • G-protein coupled receptor 49
      • G-protein coupled receptor 67
      • G-protein coupled receptor HG38
      Background InformationLGR5 (Leucine-rich repeat G protein-coupled receptor 5) is thought of as a possible stem cell marker for the hair follicle and the epithelium of the intestine. LGR5 is only expressed in cycling crypt base columnar cells, which are thought to be genuine intestinal stem cells. LGR5 has also been implicated as a negative regulator of the Wnt signaling pathway. LGR5 is often up-regulated in certain cancers and may play a role in cancer cell progression.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-LGR5 (GPR49) Antibody is an antibody against LGR5 (GPR49) for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of human LGR5.
      EpitopeCytoplasmic Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes LRG5 at the cytoplasmic domain.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human.
      Other homologies: Rat (73% sequence homology). No homology to Mouse was found.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • LGR5
      • GPR49
      • GPR67
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.

      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

      TISSUE SPECIFICITY: Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.

      SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 1 family.

      Contains 16 LRR (leucine-rich) repeats.

      Contains 1 LRRNT domain.
      Molecular Weight~95 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected LGR5 in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies