AB9374 | Anti-LR11 Antibody

AB9374
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB9374
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-LR11 Antibody
      Alternate Names
      • low-density lipoprotein receptor relative with 11 binding repeats
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide.
      Applications
      ApplicationAnti-LR11 Antibody is an antibody against LR11 for use in WB.
      Key Applications
      • Western Blotting
      Application NotesImmunoblotting: 0.5-1.0 μg/mL on HEK cells transfected with LR11. The antibody reacts with the ~250 kD LR11 protein.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from human LR11.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes LR11 [low-density lipoprotein receptor relative with 11 binding repeats].
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein that belongs to the families of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins, of low density lipoprotein receptor (LDLR) proteins, and of fibronectin type III repeats proteins. In addition to VPS10, LDLR and fibronectin type 3 domains, this protein also includes an epidermal growth factor precursor-like module, a single transmembrane segment and a cytoplasmic tail with features similar to endocytosis- and sorting-competent receptors. Members of the VPS10 domain-containing receptor family are large with many exons but the CDS lengths are usually less than 3700 nt; this gene is an exception to the pattern with a CDS length greater than 6600 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. The encoded protein is mainly intracellular and localizes in the paranuclear compartment. It is synthesized as a preproprotein, and when the propeptide is still attached, no binding occurs to the VPS10 domain. This gene is strongly expressed in the central nervous system.
      Gene Symbol
      • SORL1
      • LR11
      • LRP9
      • SorLA
      • SORLA
      • SorLA-1
      • gp250
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q92673 # Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction.
      SIZE: 2214 amino acids; 248441 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
      TISSUE SPECIFICITY: Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to Ref.1, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to Ref.2, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
      PTM: The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.
      SIMILARITY: SwissProt: Q92673 ## Contains 5 BNR repeats. & Contains 1 EGF-like domain. & Contains 6 fibronectin type-III domains. & Contains 11 LDL-receptor class A domains. & Contains 5 LDL-receptor class B repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications