PC709 | Anti-MYH (33-51) Rabbit pAb

PC709
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      H, RRbPolyclonal Antibody

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      PC709-100UL
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      In Stock 
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          Glass bottle 100 ul
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          Description
          OverviewRecognizes the MYH protein and several of its approximately 10 isoforms in PC12, Jurkat, and HeLa cells.
          Catalogue NumberPC709
          Brand Family Calbiochem®
          SynonymsAnti-MutY Homolog
          References
          ReferencesWang, G., et al. 2000. Nucleic Acids Res. 28, 2135.
          Product Information
          FormLiquid
          FormulationUndiluted serum.
          Positive controlPC12, Jurkat, or HeLa cells
          Preservative≤0.1% sodium azide
          Applications
          Application ReferencesParaffin Sections Barouch, L.A., et al. 2006. Circ. Res. 98, 119.
          Key Applications Immunoblotting (Western Blotting)
          Immunofluorescence
          Paraffin Sections
          Application NotesImmunoblotting (1:1500)
          Immunofluorescence (1:500)
          Paraffin Sections (see application references)
          Application CommentsDetects MYH and several of its approximately ten isoforms. In Jurkat cells the ~52 kDa and ~53 kDa variants were found in the nuclear fraction while the ~57 kDa protein is found in the mitochondria. Antibody should be titrated for optimal results in individual systems.
          Biological Information
          Immunogena synthetic peptide (QEGRQKHAKNNSQAKPSAC) corresponding to amino acids 33-51 of human MYH
          ImmunogenHuman
          HostRabbit
          IsotypeIgG
          Species Reactivity
          • Human
          • Rat
          Antibody TypePolyclonal Antibody
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          PC709

          References

          Reference overview
          Wang, G., et al. 2000. Nucleic Acids Res. 28, 2135.

          Citations

          Title
        • Barouch, L.A., et al. 2006. Circulation Research 98, 119.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-October-2007 RFH
          SynonymsAnti-MutY Homolog
          ApplicationImmunoblotting (1:1500)
          Immunofluorescence (1:500)
          Paraffin Sections (see application references)
          DescriptionRabbit polyclonal antibody supplied as undiluted serum. Recognizes the ~52-57 kDa isoforms of MYH.
          BackgroundOxidative DNA base lesions such as 8-oxoguanine (8-oxoG) are frequently mutagenic and have been implicated in a variety of pathophysiological states including cancer, Alzheimer's disease, arthritis, and cardiovascular disease. These lesions are generated by oxidative stress. MYH is a mammalian homolog of the E. coli Mut Y DNA glycosylase that excises adenine residues misincorporated opposite the oxidized base, 8-oxoG. MYH up-regulation can be observed following damage in mitochondrial DNA. Single mutations in this protein result in reduced translation efficiency of transcripts. Mutations in MYH have been observed in human colorectal tumors and lung cancer cell lines.
          HostRabbit
          Immunogen speciesHuman
          Immunogena synthetic peptide (QEGRQKHAKNNSQAKPSAC) corresponding to amino acids 33-51 of human MYH
          IsotypeIgG
          Specieshuman, rat
          Positive controlPC12, Jurkat, or HeLa cells
          FormLiquid
          FormulationUndiluted serum.
          Preservative≤0.1% sodium azide
          CommentsDetects MYH and several of its approximately ten isoforms. In Jurkat cells the ~52 kDa and ~53 kDa variants were found in the nuclear fraction while the ~57 kDa protein is found in the mitochondria. Antibody should be titrated for optimal results in individual systems.
          Storage -20°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesWang, G., et al. 2000. Nucleic Acids Res. 28, 2135.
          Citation
        • Barouch, L.A., et al. 2006. Circulation Research 98, 119.
        • Application referencesParaffin Sections Barouch, L.A., et al. 2006. Circ. Res. 98, 119.