ABT407 | Anti-MYOZAP Antibody

ABT407
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABT407
      DescriptionAnti-MYOZAP Antibody
      Alternate Names
      • Myocardial zonula adherens protein
      • GRINL1A upstream protein
      • Gup
      Background InformationMyocardial zonula adherens protein, also known as GRINL1A upstream protein (Gup), and encoded by the gene name MYZAP or MYOZAP, is a 54 kDa highly conserved cardiac protein. It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase–RhoA interacting protein (MRIP) and acts as an activator of Rhodependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, Nmethyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Applications
      ApplicationAnti-MYOZAP Antibody detects level of MYOZAP & has been published & validated for use in MYOZAP.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the C-terminus of human MYOZAP.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • MYZAP
      • MYOZAP
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~54 kDa observed. Uncharacterized bands may be observed in some lysate(s). Uniprot describes 11 isoforms produced by alternative splicing ranging between ~44 kDa and ~54 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat kidney tissue lysate.

      Western Blotting Analysis: 1 μg/mL of this antibody detected MYOZAP in rat kidney tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies