AB1224 | Anti-Myeloperoxidase Antibody, human white cell

AB1224
2 mL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB1224
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Myeloperoxidase Antibody, human white cell
      Alternate Names
      • MPO
      References
      Product Information
      FormatSerum
      PresentationMonospecific antiserum purified by delipidation and defibrination. Lyophilized from 0.02 M Potassium Phosphate buffer, 0.15 M Sodium Chloride, pH 7.2, 0.01% Sodium Azide. Reconstitute with 2.0 mL of sterile distilled water.
      Applications
      ApplicationAnti-Myeloperoxidase Antibody, human white cell is an antibody against Myeloperoxidase for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesImmunoblotting: antibody recognizes alpha and beta subunits of MPO. Reduced and denatured extracts of purified MPO produce blots produce 55-60kDa alpha subunits and 12-14kDa beta subunit bands140 Additional bands may be present due to cross reactivity with other myeloperoxidases.

      ELISA:

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenMyeloperoxidase (Human White Cells)
      Epitopehuman white cell
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityMyeloperoxidase (Human White Cells). Monospecific by IEP. Some cross reactivity with Myeloperoxidase from other tissues and species may occur.

      Myeloperoxidase (MPO) represents an early appearing and highly reliable intracellular myeloid lineage marker molecule. MPO protein can be detected in a subset of human hematopoietic bone marrow progenitor cells and in granulomonopoietic (GM) cells. However, other myeloid-related cell types such as epidermal Langerhans-type dendritic cells (LC) lack MPO. Therefore, human myeloid progenitors might be subdivided based on MPO protein expression into functional subsets.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryMyeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils.
      Gene Symbol
      • MPO
      • myeloperoxidase
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05164 # Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
      COFACTOR: Binds 1 calcium ion per heterodimer. & Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.
      SIZE: 745 amino acids; 83869 Da
      SUBUNIT: Tetramer of two light chains and two heavy chains.
      SUBCELLULAR LOCATION: Lysosome.
      DISEASE:SwissProt: P05164 # Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
      SIMILARITY: SwissProt: P05164 ## Belongs to the peroxidase family. XPO subfamily.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore unopened vial at 2-8 ºC. Maintain frozen at -20ºC in undiluted aliquots for up to one year after reconstitution. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size2 mL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-MYELOPEROXIDASE (Human White Cells) POLYCLONAL ANTIBODY - 2407515 2407515
      RABBIT ANTI-MYELOPEROXIDASE (Human White Cells) POLYCLONAL ANTIBODY - 2444747 2444747
      RABBIT ANTI-MYELOPEROXIDASE (Human White Cells) POLYCLONAL ANTIBODY - 2445843 2445843
      RABBIT ANTI-MYELOPEROXIDASE -2649221 2649221
      RABBIT ANTI-MYELOPEROXIDASE -2685724 2685724
      RABBIT ANTI-MYELOPEROXIDASE -2764910 2764910

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress

      Technical Info

      Title
      White Paper- Modern Methods in Oxidative Stress Research

      Data Sheet

      Title
      Anti-Myeloperoxidase, human white cell - Data Sheet

      Related Products & Applications

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      Alternative Packsize

      Catalogue Number Description  
      AB1224-KC Anti-Myeloperoxidase,hu white cell (KC) Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies