MAB1628 | Anti-Myosin Antibody, slow muscle, clone NOQ7.5.4D

100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers


      Contact Customer Service

      Click To Print This Page


      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, FeRIA, WB, IHCMPurifiedMonoclonal Antibody
      Catalogue NumberMAB1628
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Myosin Antibody, slow muscle, clone NOQ7.5.4D
      Product Information
      ApplicationAnti-Myosin Antibody, slow muscle, clone NOQ7.5.4D is an antibody against Myosin for use in RIA, WB, IH.
      Key Applications
      • Radioimmunoassay
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry: frozen and formalin fixed sections.



      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenMyosin purified from myofibrils isolated from histochemically mixed human skeletal muscle.
      Epitopeslow muscle
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificitySlow myosin heavy chain. Clearly identifies Type 1 fibers. Within skeletal muscle MAB1628 is specific for slow myosin heavy chain in a wide variety of species. It reacts strongly with rat and feline slow myosin heavy chain. MAB1628 also identifies beta (slow) myosin heavy chain in heart ventricles.
      Species Reactivity
      • Human
      • Rat
      • Feline
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryMYH7 encodes the cardiac muscle beta (or slow) isoform of myosin. Changes in the relative abundance of MYH7 and MYH6 (the alpha, or fast, isoform of cardiac myosin heavy chain) correlate with the contractile velocity of cardiac muscle. Mutations in MYH7 are associated with familial hypertrophic cardiomyopathy.
      Gene Symbol
      • MYH7
      • Myosin-7
      • MYHCB
      • MyHC-beta
      • CMD1S
      • MGC138378
      • MPD1
      • DKFZp451F047
      • MGC138376
      • CMH1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P12883 # Muscle contraction.
      SIZE: 1935 amino acids; 223097 Da
      SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
      SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
      DOMAIN: SwissProt: P12883 The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
      DISEASE: SwissProt: P12883 # Defects in MYH7 are the cause of familial hypertrophic cardiomyopathy type 1 (CMH1) [MIM:192600]; also designated FHC or HCM. Hypertrophic cardiomyopathy is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. FHC is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. & Defects in MYH7 are the cause of myosin storage myopathy [MIM:608358]. In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers. & Defects in MYH7 are a cause of dilated cardiomyopathy (CMD) [MIM:115200]. CMD is a disorder characterized by cardiac dilation and reduced systolic function. & Defects in MYH7 are the cause of Laing early-onset distal myopathy (MPD1) [MIM:160500]. MPD1 is an autosomal dominant disorder which differs from other distal myopathies in that onset is as early as 4 years of age. Selective weakness of the anterior tibial muscles is followed by weakness of the finger extensors and selected proximal muscle groups such as the hip abductors and rotators, the shoulder abductors and the sternocleidomastoids.
      SIMILARITY: Contains 1 IQ domain. & Contains 1 myosin head-like domain.
      MISCELLANEOUS: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). & The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-SLOW MUSCLE MYOSIN -2530970 2530970
      MOUSE ANTI-SLOW MUSCLE MYOSIN -2586461 2586461
      MOUSE ANTI-SLOW MUSCLE MYOSIN -2629270 2629270
      MOUSE ANTI-SLOW MUSCLE MYOSIN -2637506 2637506
      MOUSE ANTI-SLOW MUSCLE MYOSIN -2643943 2643943
      MOUSE ANTI-SLOW MUSCLE MYOSIN -2658923 2658923
      MOUSE ANTI-SLOW MUSCLE MYOSIN -2697554 2697554
      MOUSE ANTI-SLOW MUSCLE MYOSIN -2726740 2726740


      Reference overviewApplicationPub Med ID
      Myotubes from severely obese type 2 diabetic subjects accumulate less lipids and show higher lipolytic rate than myotubes from severely obese non-diabetic subjects.
      Bakke, SS; Feng, YZ; Nikoli?, N; Kase, ET; Moro, C; Stensrud, C; Damlien, L; Ludahl, MO; Sandbu, R; Solheim, BM; Rustan, AC; Hjelmesæth, J; Thoresen, GH; Aas, V
      PloS one  10  e0119556  2015

      Show Abstract
      25790476 25790476
      Lipid in skeletal muscle myotubes is associated to the donors' insulin sensitivity and physical activity phenotypes.
      Bajpeyi, S; Myrland, CK; Covington, JD; Obanda, D; Cefalu, WT; Smith, SR; Rustan, AC; Ravussin, E
      Obesity (Silver Spring, Md.)  22  426-34  2014

      Show Abstract
      Immunohistochemistry23818429 23818429
      Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation.
      Covington, JD; Galgani, JE; Moro, C; LaGrange, JM; Zhang, Z; Rustan, AC; Ravussin, E; Bajpeyi, S
      PloS one  9  e91675  2014

      Show Abstract
      Immunohistochemistry24632837 24632837
      CaMKII content affects contractile, but not mitochondrial, characteristics in regenerating skeletal muscle.
      Eilers, W; Jaspers, RT; de Haan, A; Ferrié, C; Valdivieso, P; Flück, M
      BMC physiology  14  7  2014

      Show Abstract
      25515219 25515219
      Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.
      Yuen, M; Sandaradura, SA; Dowling, JJ; Kostyukova, AS; Moroz, N; Quinlan, KG; Lehtokari, VL; Ravenscroft, G; Todd, EJ; Ceyhan-Birsoy, O; Gokhin, DS; Maluenda, J; Lek, M; Nolent, F; Pappas, CT; Novak, SM; D'Amico, A; Malfatti, E; Thomas, BP; Gabriel, SB; Gupta, N; Daly, MJ; Ilkovski, B; Houweling, PJ; Davidson, AE; Swanson, LC; Brownstein, CA; Gupta, VA; Medne, L; Shannon, P; Martin, N; Bick, DP; Flisberg, A; Holmberg, E; Van den Bergh, P; Lapunzina, P; Waddell, LB; Sloboda, DD; Bertini, E; Chitayat, D; Telfer, WR; Laquerrière, A; Gregorio, CC; Ottenheijm, CA; Bönnemann, CG; Pelin, K; Beggs, AH; Hayashi, YK; Romero, NB; Laing, NG; Nishino, I; Wallgren-Pettersson, C; Melki, J; Fowler, VM; MacArthur, DG; North, KN; Clarke, NF
      The Journal of clinical investigation  124  4693-708  2014

      Show Abstract
      25250574 25250574
      Remodeling of oxidative energy metabolism by galactose improves glucose handling and metabolic switching in human skeletal muscle cells.
      Kase, ET; Nikoli?, N; Bakke, SS; Bogen, KK; Aas, V; Thoresen, GH; Rustan, AC
      PloS one  8  e59972  2013

      Show Abstract
      23560061 23560061
      Variable myopathic presentation in a single family with novel skeletal RYR1 mutation.
      Attali, R; Aharoni, S; Treves, S; Rokach, O; Becker Cohen, M; Fellig, Y; Straussberg, R; Dor, T; Daana, M; Mitrani-Rosenbaum, S; Nevo, Y
      PloS one  8  e69296  2013

      Show Abstract
      23894444 23894444
      ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling.
      Seto, JT; Quinlan, KG; Lek, M; Zheng, XF; Garton, F; MacArthur, DG; Hogarth, MW; Houweling, PJ; Gregorevic, P; Turner, N; Cooney, GJ; Yang, N; North, KN
      The Journal of clinical investigation  123  4255-63  2013

      Show Abstract
      24091322 24091322
      The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration.
      Hoshino, S; Sakamoto, K; Vassilopoulos, S; Camus, SM; Griffin, CA; Esk, C; Torres, JA; Ohkoshi, N; Ishii, A; Tamaoka, A; Funke, BH; Kucherlapati, R; Margeta, M; Rando, TA; Brodsky, FM
      PloS one  8  e77787  2013

      Show Abstract
      24204966 24204966
      Grb10 regulates the development of fiber number in skeletal muscle.
      Lowenna J Holt,Nigel Turner,Nancy Mokbel,Sophie Trefely,Timo Kanzleiter,Warren Kaplan,Christopher J Ormandy,Roger J Daly,Gregory J Cooney
      FASEB journal : official publication of the Federation of American Societies for Experimental Biology  26  2012

      Show Abstract
      22623587 22623587

      Data Sheet

      Anti-Myosin, slow muscle, clone NOQ7.5.4D - Data Sheet

      Related Products & Applications

      Related Products

      Catalogue Number Description  
      MAB1548 Anti-Myosin Antibody, heavy chain β Show Pricing & Availability

      Product Families


      Life Science Research > Antibodies and Assays > Primary Antibodies