AB120 | Anti-Norepinephrine Antibody

AB120
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RIHCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB120
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Norepinephrine Antibody
      Alternate Names
      • Arterenol
      • Noradrenaline
      Background InformationThe chemical compound norepinephrine (NC(8)O(3)H(11), also known as noradrenaline, is a catecholamine that functions as both a neurotransmitter and a hormone. It is released from the adrenal glands and also by certain neurons. It affects parts of the human brain where attention and impulsivity are controlled. This compound affects the fight-or-flight response, activating the sympathetic nervous system to directly increase heart rate, release energy from fat and increase muscle readiness.



      The host of physiological changes activated by a stressful event are unleashed in part by activation of a nucleus in the brain stem called the locus ceruleus. This nucleus is the origin of most norepinephrine pathways in the brain. Neurons using norepinephrine as their neurotransmitter project bilaterally from the locus ceruleus along distinct pathways to the cerebral cortex, limbic system, and the spinal cord, among other projections.
      References
      Product Information
      FormatSerum
      PresentationLiquid rabbit antiserum with 0.05% sodium azide.
      Applications
      ApplicationAnti-Norepinephrine Antibody is an antibody against Norepinephrine for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:200-1:500 with enhanced detection. Glutaraldehyde fixation required for reactivity. Lightly fixed 4% PFA .2-5% glutaraldehyde fixed tissue works well; permeabilization with 0.1-.2% triton X-100 in block ONLY. Dilute antibody solutions in simple buffers without excess proteins or detergents.



      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenNoradrenaline-glutaraldehyde-BSA
      HostRabbit
      SpecificityNoradrenaline: reactive with noradrenaline reacted with glutaraldehyde; glutaraldehyde required in fixation for reactivity; reactivity with free noradrenaline is very poor.



      The cross-reactivities were determined using either ELISA or RIA techniques, at concentration/unconjugated or conjugated amino acid concentration at half displacement.



      Compound Cross-reactivity

      Noradrenaline-G-BSA 1.0

      Octopamine-G-BSA 0.032

      Dopamine-G-BSA 0.016

      Adrenaline-G-BSA 0.006

      Noradrenaline 0.0002

      L-Dopa-G-BSA 0.0002

      p-Tryamine-G-BSA 0.0002



      *The antisera was also tested for specificity using the free-floating PAP technique on rat locus coeruleus.

      Abbreviations:

      (BSA)= Bovine serum albumin

      G)= Glutaraldehyde
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-NORADRENALINE (ARTERENOL) -2698372 2698372
      RABBIT ANTI-NORADRENALINE (ARTERENOL) POLYCLONAL ANTIBODY - 2138531 2138531
      RABBIT ANTI-NORADRENALINE (ARTERENOL) POLYCLONAL ANTIBODY - 2385933 2385933
      RABBIT ANTI-NORADRENALINE (ARTERENOL) POLYCLONAL ANTIBODY - 2435062 2435062
      RABBIT ANTI-NORADRENALINE (ARTERENOL) POLYCLONAL ANTIBODY - 2443987 2443987
      RABBIT ANTI-NORADRENALINE (ARTERENOL) POLYCLONAL ANTIBODY - 2449972 2449972
      RABBIT ANTI-NORADRENALINE (ARTERENOL) POLYCLONAL ANTIBODY - 2454686 2454686
      RABBIT ANTI-NORADRENALINE (ARTERENOL) POLYCLONAL ANTIBODY - 2460926 2460926
      RABBIT ANTI-NORADRENALINE (ARTERENOL) POLYCLONAL ANTIBODY - 2165806 2165806
      RABBIT ANTI-NORADRENALINE (ARTERENOL) POLYCLONAL ANTIBODY - 2273926 2273926

      References

      Reference overviewApplicationSpeciesPub Med ID
      A thermogenic secondary sexual character in male sea lamprey.
      Chung-Davidson, YW; Priess, MC; Yeh, CY; Brant, CO; Johnson, NS; Li, K; Nanlohy, KG; Bryan, MB; Brown, CT; Choi, J; Li, W
      The Journal of experimental biology  216  2702-12  2013

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      23804672 23804672
      Evidence for involvement of Wnt signalling in body polarities, cell proliferation, and the neuro-sensory system in an adult ctenophore.
      Jager, M; Dayraud, C; Mialot, A; Quéinnec, E; le Guyader, H; Manuel, M
      PloS one  8  e84363  2013

      Show Abstract
      24391946 24391946
      Role of key aromatic residues in the ligand-binding domain of alpha7 nicotinic receptors in the agonist action of beta-amyloid.
      Tong, M; Arora, K; White, MM; Nichols, RA
      The Journal of biological chemistry  286  34373-81  2011

      Show Abstract
      Western Blotting21828053 21828053
      Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells.
      Schreiner, S; Wimmer, P; Groitl, P; Chen, SY; Blanchette, P; Branton, PE; Dobner, T
      Journal of virology  85  8752-65  2011

      Show Abstract
      21697482 21697482
      Adenovirus type 5 early region 1B 156R protein promotes cell transformation independently of repression of p53-stimulated transcription.
      Sieber, T; Dobner, T
      Journal of virology  81  95-105  2007

      Show Abstract Full Text Article
      17050591 17050591
      Adrenergic signalling between rat taste receptor cells.
      Herness, Scott, et al.
      J. Physiol. (Lond.), 543: 601-14 (2002)  2002

      Rat12205193 12205193
      Adrenergic signalling between rat taste receptor cells.
      Herness, Scott, et al.
      J. Physiol. (Lond.), 543: 601-14 (2002)  2002

      Rat12205193 12205193
      Immediate early and early lytic cycle proteins are frequent targets of the Epstein-Barr virus-induced cytotoxic T cell response.
      Steven, NM; Annels, NE; Kumar, A; Leese, AM; Kurilla, MG; Rickinson, AB
      The Journal of experimental medicine  185  1605-17  1997

      Show Abstract
      9151898 9151898
      Immunocytochemical study of catecholaminergic neurons in the senescence-accelerated mouse (SAM-P8) brain.
      N Karasawa,I Nagatsu,K Sakai,T Nagatsu,K Watanabe,M Onozuka
      Journal of neural transmission (Vienna, Austria : 1996)  104  1997

      Show Abstract
      9503272 9503272
      Spinal projections of the locus coeruleus and the nucleus subcoeruleus in the Harlan and the Sasco Sprague-Dawley rat.
      Sluka, K A and Westlund, K N
      Brain Res., 579: 67-73 (1992)  1992

      Show Abstract
      1623408 1623408

      Data Sheet

      Title
      Anti-Norepinephrine - Data Sheet