AB5745 | Anti-Opsin Antibody, Red/Green

AB5745
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RELISA, WBChAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5745
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Opsin Antibody, Red/Green
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
      Applications
      ApplicationDetect Opsin using this Anti-Opsin Antibody, Red/Green validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesImmunoblotting: 1:500:1:2,000 on mouse brain extract. To minimize background staining it is suggested that you include a higher content of detergent (Tween-20) in your dilution and washing solutions.

      Immunohistochemistry: not tested. It is recommended that you try the antibody at 1:50-1:1,000.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptides from mouse green opsin and zebra finch red opsin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostChicken
      SpecificityOpsin, red and green. The antibody reacts with a protein of ~40 kDa.
      Species Reactivity
      • Mouse
      • Rat
      Species Reactivity NoteRat and mouse.


      Other species have not been tested.


      It is expected that the antibody will also react with zebra finch.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness.
      Gene Symbol
      • OPN1LW
      • CBP
      • CBBM
      • RCP
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04000 # Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
      SIZE: 364 amino acids; 40572 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: The three color pigments are found in the cone photoreceptor cells.
      PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
      DISEASE:SwissProt: P04000 # Defects in OPN1LW are the cause of partial colorblindness protan series (CBP) [MIM:303900]; also called protanopia.SIMILARITY:SwissProt: P04000 ## Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      CHICKEN ANTI-OPSIN, RED/GREEN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2147015 2147015
      CHICKEN ANTI-OPSIN, RED/GREEN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2373520 2373520
      CHICKEN ANTI-OPSIN, RED/GREEN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2462790 2462790
      CHICKEN ANTI-OPSIN, RED/GREEN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2008991 2008991
      CHICKEN ANTI-OPSIN, RED/GREEN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2042719 2042719
      CHICKEN ANTI-OPSIN, RED/GREEN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2281632 2281632

      References

      Reference overviewApplicationSpeciesPub Med ID
      Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina.
      Roberts, MR; Hendrickson, A; McGuire, CR; Reh, TA
      Investigative ophthalmology & visual science  46  2897-904  2005

      Show Abstract
      ImmunohistochemistryMouse16043864 16043864

      Data Sheet

      Title
      CHICKEN ANTI-OPSIN, RED/GREEN AFFINITY PURIFIED POLYCLONAL ANTIBODY - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies