MABS738 | Anti-PMP70, clone EPR5614, Rabbit Monoclonal Antibody

MABS738
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, FCRbUnpurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS738
      DescriptionAnti-PMP70, clone EPR5614, Rabbit Monoclonal Antibody
      Alternate Names
      • ATP-binding cassette sub-family D member 3
      • 70 kDa peroxisomal membrane protein
      • PMP70
      Background InformationATP-binding cassette sub-family D member 3, also known as 70 kDa peroxisomal membrane protein (PMP70), and encoded by the gnee names ABCD3 or PMP70 or PXMP1, is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). PMP70 is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters, which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations in PMP70 have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders.
      References
      Product Information
      FormatUnpurified
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      Applications
      ApplicationThis Anti-PMP70, clone EPR5614, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of PMP70.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: A 1:100-250 dilution from a representative lot detected PMP70 in HepG2 cells.

      Produced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to the C-terminus of human PMP70.
      EpitopeC-terminus
      CloneEPR5614
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • ABCD3
      • PMP70
      • PXMP1
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~70 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293, SH-SY5Y, Caco-2, and HepG2 cell lysates.

      Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected PMP70 in HEK293, SH-SY5Y, Caco-2, and HepG2 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications