MABS731 | Anti-PON1, clone EPR2893, Rabbit Monoclonal Antibody

100 µL  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbUnpurifiedMonoclonal Antibody
      Catalogue NumberMABS731
      DescriptionAnti-PON1, clone EPR2893, Rabbit Monoclonal Antibody
      Alternate Names
      • Serum paraoxonase/arylesterase 1
      • PON 1
      • Aromatic esterase 1
      • A-esterase 1
      • K-45
      • Serum aryldialkylphosphatase 1
      Background InformationSerum paraoxonase/arylesterase 1 (PON 1), also known as Aromatic esterase 1 (A-esterase 1) or K-45 or Serum aryldialkylphosphatase 1, and encoded by the gene name PON1 or PON, is an esterase and lactonase that is synthesized in the liver and secreted into blood, associated exclusively with high density lipoproteins that belongs to the paraoxonase family. PON1 hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. This protein has been implicated in protection from atherosclerosis. PON 1 possesses both antioxidant and anti-inflammatory properties. Protecting LDL and HDL from lipid peroxidation, PON 1 degrades specific oxidized cholesteryl esters and oxidized phospholipids contained in lipoproteins. PON1 is expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. Mutations in PON1 have been associated with Microvascular complications of diabetes 5.
      Product Information
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      ApplicationThis Anti-PON1, clone EPR2893, Rabbit Monoclonal Antibody is validated for use in Western Blotting for the detection of PON1.
      Key Applications
      • Western Blotting
      Application NotesProduced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to human PON1.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • PON1
      • PON
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~40 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human fetal kidney, human ovary cancer, human fetal liver, and human plasma lysates.

      Western Blotting Analysis: A 1:10,000-50,000 dilution of this antibody detected PON1 in human fetal kidney, human ovary cancer, human fetal liver, and human plasma lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information