ABS563 | Anti-S1P Lyase Antibody

ABS563
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS563
      DescriptionAnti-S1P Lyase Antibody
      Alternate Names
      • Sphingosine-1-phosphate lyase 1
      • S1PL
      • SP-lyase 1
      • SPL 1
      • hSPL
      • Sphingosine-1-phosphate aldolase
      • S1P Lyase
      Background InformationSphingosine-1-phosphate lyase 1 (EC 4.1.2.27; UniProt O95470; also known as hSPL, S1P lyase, Sphingosine-1-phosphate aldolase, SPL 1, SP-lyase 1) is a type III single-pass ER membrane protein encoded by the SGPL1 (Also known as S1PL, SPL) gene in human (Gene ID 8879). SP-lyase 1 catalyzes the irreversible retro-aldol cleavage of sphingosine 1-phosphate to 2-hexadecenal and phosphoethanolamine. S1P lyase activity knockout is reported to offer protection in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS), by preventing T cell egress from the lymph nodes into central nervous system (CNS). S1P lyase overexpression is also demonstrated to potentiate serum withdrawal-induced apoptosis in HEK293 cultures.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-S1P Lyase Antibody is an antibody against S1P Lyase for use in Western Blotting, Immunohistochemistry .
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected S1P Lyase in human liver and human kidney tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of human S1P Lyase.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Chimpanzee, Horse, Porcine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SGPL1
      • KIAA1252
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~70 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human liver tissue lysate.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected S1P Lyase in 10 µg of human liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications