MABC988 | Anti-TRADD Antibody, clone 1G6.1

MABC988
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC988
      DescriptionAnti-TRADD Antibody, clone 1G6.1
      Alternate Names
      • Tumor necrosis factor receptor type 1-associated DEATH domain protein
      • TRADD
      • TNFR1-associated DEATH domain protein
      • TNFRSF1A-associated via death domain
      Background InformationTumor necrosis factor receptor type 1-associated DEATH domain protein (UniProt Q15628; also known as TNFR1-associated death domain protein, TNFRSF1A-associated via death domain, Tumor necrosis factor receptor-1-associated protein) is encoded by the TRADD (also known as Hs.89862) gene (Gene ID 8717) in human. TRADD is an adapter protein that interacts with the TNFR1 receptor, and mediates the activation of programmed cell death and NF-κB activation. TRADD exhibits similar structural and functional features, as well as subcellular localization as the adaptor protein Fas-associated death domain (FADD). Both proteins contain a C-terminal death domain (DD) and function as mediators of death receptors-mediated signaling pathways.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-TRADD Antibody, clone 1G6.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of TRADD.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRADD in human small intestine, human lymphoma, rat colon, and rat spleen tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human TRADD.
      Clone1G6.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityReactivity toward human TRADD spliced isoform 2 has not been determined.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TRADD
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~35 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected TRADD in 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies