MABN370 | Anti-Tachykinin-3 Antibody, clone 15D9.1

MABN370
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN370
      DescriptionAnti-Tachykinin-3 Antibody, clone 15D9.1
      Alternate Names
      • Tachykinin-3
      • ZNEUROK1
      • Neurokinin-B
      • NKB
      • Neuromedin-K
      Background InformationTachykinin-3 (TAC3), also known as ZNEUROK1 (NKB) or Neuromedin-K, encoded by the gene TAC3 or NKNB. TAC3 is a secreted peptide expressed in the CNS and PNS that can act as a neurotransmitter and excite neurons and cause behavioral changes. TAC3 is a ligand for the neurokinin-3 receptor. TAC3 is also a critical central regulator of gonadal function. Mutations in TAC3 are associated with hypogonadotropism. TAC3 is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Applications
      ApplicationDetect Tachykinin using this mouse monoclonal antibody, Anti-Tachykinin-3 Antibody, clone 15D9.1 validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500 and 1:50 dilution from a representative lot detected Tachykinin-3 in human frontal lobe and placenta tissues.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Tachykinin-3.
      Clone15D9.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgMκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TAC3
      • NKNB
      Purification MethodIon-exchange chromatography
      UniProt Number
      Molecular Weight15 kDa calculated. Uniprot describes three isoforms at 13 kDa (isoform 1), 15 kDa (isoform 2), and 11 kDa (isoform 3). A 7 kDa recombinant form of this protein was tagged with GST (26 kDa), tested in Western Blot, was observed at ~32 kDa. This protein is known to be secreted.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting of GST-tagged Tachykinin-3 recombinant protein.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected Tachykinin-3 in 10 µg of GST-tagged Tachykinin-3 recombinant protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications