ABC848 | Anti-Toso Antibody

ABC848
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC848
      DescriptionAnti-Toso Antibody
      Alternate Names
      • Fas apoptotic inhibitory molecule 3
      • Regulator of Fas-induced apoptosis Toso
      • Toso
      Background InformationApoptosis is an important process by which normal tissue homeostasis and function are maintained. Toso (also known as Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis and FAIM3) is a novel regulator of Fas-induced apoptosis in lymphoid cells and when overexpressed in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Applications
      ApplicationAnti-Toso Antibody is a highly specific rabbit polyclonal antibody, that targets Fas apoptotic inhibitory molecule 3 & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a 13 amino acid peptide near the C-terminus of human Toso.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • FAIM3
      • TOSO
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~60 kDa observed.
      Despite its predicted molecular weight of 43 kDa, Toso often migrates at 60 kDa in western blots.
      Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human lung tissue lysate with and without blocking peptide.

      Western Blotting Analysis: 1 μg/mL of this antibody detected Toso in human lung tissue lysate with and without blocking peptide.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications