AB18000 | Anti-Zebrafish Integrin beta3 Antibody

AB18000
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      ZebrafishWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB18000
      DescriptionAnti-Zebrafish Integrin beta3 Antibody
      Alternate Names
      • CD61 antigen
      • Platelet membrane glycoprotein IIIa
      • integrin beta chain, beta 3
      • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
      • platelet glycoprotein IIIa
      Background InformationIntegrin beta3 is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. Heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins in extracellular matrix and/or adjacent cells. Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways. Phosphorylation of tyrosine 773 on integrin beta3 activates the receptor and promotes cell adhesion.Tyr773 is commonly referred to as Tyr747, the corresponding site in the chicken integrin beta3 protein.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Zebrafish Integrin beta3 transfected and nontransfected CHO cell lysates.
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationAnti-Zebrafish Integrin beta3 Antibody detects level of Zebrafish Integrin beta3 & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to zebrafish Integrin beta3.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThe antibody recognizes zebrafish Integrin beta3.
      Species Reactivity
      • Zebrafish
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ITGB3
      • CD61
      • GP3A
      • GPIIIa
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummarySUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein By similarity.

      SEQUENCE SIMILARITIES: Belongs to the integrin beta chain family.
      Molecular Weight~ 100 kDa is observed; the calculated MW of 88 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western blot in zebrafish Integrin beta3 transfected and nontransfected CHO cell lysates.

      Western blot Analysis: 0.1 µg/mL of this antibody detected Integrin beta3 in transfected and nontransfected CHO cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications