ABE361 | Anti-acetyl-Histone H4 (Lys91) Antibody

ABE361
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, DBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE361
      DescriptionAnti-acetyl-Histone H4 (Lys91) Antibody
      Alternate Names
      • Histone H4
      Background InformationHistones are nuclear proteins that form octameric structures which bind DNA to form units of chromatin called nucleosomes. The family of histones—H2A, H2B, H3, and H4—are key players in gene regulation. They undergo a number of post-translational modifications (PTM) in response to various stimuli. Acetylation is a reversible PTM that involves the transfer of acetyl groups to N-terminal lysine (K) residues by the family of histone acetyltransferase enzymes, including GNAT, Gcn5, and p300/CBP. Histone acetylation reduces the electrostatic attractions between DNA and histones, which typically destabilizes chromatin structure and provide chromatin remodeling and transcriptional complexes with access to DNA, potentially resulting in increased gene transcription. Recent studies have suggested that acetylation of histone H4 lysine 91 facilitates the interaction of H3/H4 tetramers with H2A/H2B dimers, which is required for chromatin assembly.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Untreated and sodium butyrate treated HeLa acid extract and recombinant Histone H4
      PresentationPurified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-acetyl-Histone H4 is an antibody against acetyl-Histone H4 for use in WB & Dot Blot.
      Key Applications
      • Western Blotting
      • Dot Blot
      Application NotesDot Blot Analysis: A representative lot detected acetylated Histone H4 (Lys91) in an AbSurance™ Histone H2A, H2B, H4 Antibody Specificity Array (Cat. No. 16-665).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Histone H4 acetylated at Lys91.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Histone H4 acetylated at Lys91.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human. Expected to react with most mammals due to conserved homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HIST1H4A
      • H4/A
      • H4FA
      • HIST1H4B
      • H4/I
      • H4FI
      • HIST1H4C
      • H4/G
      • H4FG
      • HIST1H4D
      • H4/B
      • H4FB
      • HIST1H4E
      • H4/J
      • H4FJ
      • HIST1H4F
      • H4/C
      • H4FC
      • HIST1H4H
      • H4/H
      • H4FH
      • HIST1H4I
      • H4/M
      • H4FM
      • HIST1H4J
      • H4/E
      • H4FE
      • HIST1H4K
      • H4/D
      • H4FD
      • HIST1H4L
      • H4/K
      • H4FK
      • HIST2H4A
      • H4/N
      • H4F2
      • H4FN
      • HIST2H4
      • HIST2H4B
      • H4/O
      • H4FO
      • HIST4H4
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~13 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in untreated and sodium butyrate treated HeLa acid extract and recombinant Histone H4.

      Western Blot Analysis: A 1:2,000 dilution from a representative lot detected acetylated Histone H4 (Lys91) in 10 µg of sodium butyrate treated HeLa acid extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies