MABT78 | Anti-mouse CD44 (H-CAM) Antibody, clone KM201

MABT78
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT78
      ReplacesCBL1308
      DescriptionAnti-mouse CD44 (H-CAM) Antibody, clone KM201
      Alternate Names
      • CD44 antigen (homing function and Indian blood group system)
      • CDw44 antigen
      • HCAM
      • H-CAM
      • HUTCH-1
      • Phagocytic glycoprotein I
      • Extracellular matrix receptor III
      • GP90 lymphocyte homing/adhesion receptor
      • Heparan sulfate proteoglycan
      • Hermes antigen
      • Hyaluronate receptor
      • Epican
      • antigen gp90 homing receptor
      • chondroitin sulfate proteoglycan 8
      • hematopoietic cell E- and L-selectin ligand
      Background InformationCD44, also known as H-CAM is a distinct adhesion molecule that, with its 13 known isoforms, comprises a family of transmembrane glycoproteins involved in a wide variety of significant biological processes. Members belonging to this family are involved in apoptosis, migration, metastasis, tumor progression, lymphocyte homing, and the attachment of hematopoietic cells to stromal cells. CD44 is the primary cell surface receptor for hyaluronic acid (HA), and is also a notable target for WNT signaling within the intestinal mucosa. Recent studies have used CD44 marker as a means to isolate different cancer stem cells (CSC) such as; colorectal CSC, pancreatic CSC, and prostate CSC.
      References
      Product Information
      FormatPurified
      Control
      • Mouse bone marrow cells
      PresentationPurified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
      Applications
      ApplicationDetect mouse CD44 (H-CAM) using this Anti-mouse CD44 (H-CAM) Antibody, clone KM201 validated for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenMouse bone marrow-derived stromal cells
      EpitopeNear the hyaluronate binding domain
      CloneKM201
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificityThe antibody recognizes CD44 near the hyaluronate binding domain.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD44
      • CD44R
      • CDW44
      • CDw44
      • CSPG8
      • ECMR-III
      • Epican
      • HCELL
      • HUTCH-I
      • IN
      • LHR
      • MC56
      • MDU2
      • MDU3
      • MIC4
      • MUTCH-I
      • PGP-1
      • PGP-I
      • Pgp1
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      PTM: N-glycosylated By similarity.

      O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated (By similarity).

      Phosphorylated; activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708 (By similarity).

      POLYMORPHISM: Two allelic forms of this glycoprotein, PGP-1.1 and PGP-1.2, have been reported. The expressed product is PGP-1.1 (Ly-24.1).

      SEQUENCE SIMILARITIES: Contains 1 Link domain.
      Molecular Weight86 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in mouse bone marrow cells.

      Flow Cytometry Analysis: 0.1 µg of this antibody detected CD44 in mouse bone marrow cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-mouse CD44 (H-CAM), clone KM201 - 2000052 2000052
      Anti-mouse CD44 (H-CAM), clone KM201 - 2015588 2015588
      Anti-mouse CD44 (H-CAM), clone KM201 - 2066319 2066319
      Anti-mouse CD44 (H-CAM), clone KM201 - 2168282 2168282
      Anti-mouse CD44 (H-CAM), clone KM201 - 2203078 2203078
      Anti-mouse CD44 (H-CAM), clone KM201 - 2207214 2207214
      Anti-mouse CD44 (H-CAM), clone KM201 - 2827670 2827670
      Anti-mouse CD44 (H-CAM), clone KM201 - NRG1765533 NRG1765533

      References

      Reference overviewPub Med ID
      The inhibition of hyaluronan degradation reduced pro-inflammatory cytokines in mouse synovial fibroblasts subjected to collagen-induced arthritis.
      Giuseppe M Campo,Angela Avenoso,Angela D'Ascola,Michele Scuruchi,Vera Prestipino,Giancarlo Nastasi,Alberto Calatroni,Salvatore Campo
      Journal of cellular biochemistry  113  2012

      Show Abstract
      22234777 22234777

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies