MABE339 | Anti-p53 (wild type) Antibody, clone PAb1620

MABE339
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE339
      DescriptionAnti-p53 (wild type) Antibody, clone PAb1620
      Alternate Names
      • Cellular tumor antigen p53
      • Tumor suppressor p53
      Background InformationWild-type p53 is present in the nucleus of all normal mammalian cells where it appears to be involved in the regulation of cell proliferation. The normal protein has a very short half-life and is present in only minute amounts in normal tissues and cells. In contrast, mutant p53 protein produced by malignant cells is usually a product of a point mutation in the p53 gene leading to substitution of a single amino acid that significantly prolongs the half-life of the protein. The accumulation of high levels of p53 is a potential novel marker for malignancy.
      References
      Product Information
      FormatPurified
      Control
      • Mouse brain tissue lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-p53 (wild type) Antibody, clone PAb1620 is a Mouse Monoclonal Antibody for detection of p53 (wild type) also known as Cellular tumor antigen p53, Tumor suppressor p53 & has been validated in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution of this antibody detected p53 in normal human brain tissue.

      Immunoprecipitation Analysis: A representative lot from an independent laboratory detected p53 in IP (Lu, X., et al. (1992). Cell. 70(1):153-161.).

      Immunohistochemistry Analysis: A representative lot from an independent laboratory detected p53 in dorsal skin samples from animal trunks (Kramata, P., et al. (2005). Cancer Res. 65(9):3577-3585.) and in certain human cancer tissues (Cordon-Cardo, C., et al, (1991). 51(23 Pt 1):6372-6380.).
      Biological Information
      ImmunogenMouse VLM tumor cells.
      ClonePab1620
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Tp53
      • P53
      • Trp53
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~53 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse brain tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected p53 in mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-p53 (wild type), clone PAb1620 2480953
      Anti-p53 (wild type), clone PAb1620 - 2397843 2397843
      Anti-p53 (wild type), clone PAb1620 - Q2015739 Q2015739
      Anti-p53 (wild type), clone PAb1620 -2514231 2514231
      Anti-p53 (wild type), clone PAb1620 -2550993 2550993
      Anti-p53 (wild type), clone PAb1620 -2618684 2618684
      Anti-p53 (wild type), clone PAb1620 -2623699 2623699
      Anti-p53 (wild type), clone PAb1620 -2646505 2646505
      Anti-p53 (wild type), clone PAb1620 -2685237 2685237
      Anti-p53 (wild type), clone PAb1620 -2710618 2710618

      References

      Reference overviewPub Med ID
      Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkpoint proteins p21, p27 and p53 in cervical carcinomas.
      Liu, X; Yang, WT; Zheng, PS
      Oncotarget  5  10870-85  2014

      Show Abstract
      25362645 25362645
      Patches of mutant p53-immunoreactive epidermal cells induced by chronic UVB Irradiation harbor the same p53 mutations as squamous cell carcinomas in the skin of hairless SKH-1 mice.
      Kramata, Pavel, et al.
      Cancer Res., 65: 3577-85 (2005)  2005

      Show Abstract
      15867351 15867351
      Ras-induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation.
      Lu, X, et al.
      Cell, 70: 153-61 (1992)  1992

      Show Abstract
      1623518 1623518
      Expression of HLA-A,B,C antigens on primary and metastatic tumor cell populations of human carcinomas.
      Cordon-Cardo, C, et al.
      Cancer Res., 51: 6372-80 (1991)  1991

      Show Abstract
      1933900 1933900

      Brochure

      Title
      New Products: Volume 3, 2012

      Newsletters / Publications

      Title
      Research Focus - Volume 5 2012

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies