14-574M | EphA4 Protein, active, 250 µg

14-574M
250 µg  Also available in 10 μg size (cat#14-574) and in bulk (cat# 14-574-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-574M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionEphA4 Protein, active, 250 µg
      OverviewN-terminal His6-tagged recombinant human EphA4 residues 601-892
      References
      Product Information
      Applications
      ApplicationActive, N-terminal His6-tagged recombinant human EphA4 residues 601-892, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
      Gene Symbol
      • EPHA4
      • Hek8
      • HEK8
      • EphA4
      • TYRO1
      • SEK
      Protein TargetEphA4
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P54764 # Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.
      SIZE: 986 amino acids; 109860 Da
      SUBUNIT: Interacts with the src family kinase, p59-Fyn, through the major phosphorylation site at position Tyr-602. Interacts with NGEF/ephexin-1 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Ubiquitous.
      DOMAIN: SwissProt: P54764 The protein kinase domain mediates interaction with NGEF/ephexin-1 (By similarity).
      SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
      Molecular Weight37kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-574) and in bulk (cat# 14-574-K).
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-574 EphA4 Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases