AG230 | Glial Fibrillary Acidic Protein, porcine

AG230
100 µg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberAG230
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionGlial Fibrillary Acidic Protein, porcine
      OverviewPurified porcine Glial Fibrillary Acidic Protein (GFAP) purified from spinal cord.
      Alternate Names
      • GFAP
      Background InformationGlial fibrillary acidic protein (UniProt F1RR02) is encoded by the GFAP gene (Gene ID 396562) in porcine. GFAP is a type III intermediate filament (IF) thought to help maintain astrocyte mechanical strength and is closely related to vimentin, desmin, and peripherin, which are involved in the structure and function of cellular cytoskeleton. GFAP is expressed in astrocytes in the central nervous system (CNS), where it is involved in many important CNS processes, including cell communication and the blood brain barrier (BBC) function. GFAP contains the characteristic tripartite domain structure among IF members, a central α-helical rod domain (a.a. 73-377) flanked by a non-α-helical N-terminal head (a.a. 1-72) and a C-terminal tail (a.a. 378-432) domain. The head and tail domains are most structurally variable among IF proteins and their contributions to filament assembly vary depending on the IF proteins. For GFAP, the tail domain is reported to be important for filament assembly. The tail domain R416W mutation is linked to the neurological disorder Alexander disease (AxD).
      References
      Product Information
      PresentationLiquid. Buffer = PBS.
      Applications
      Key Applications
      • Western Blotting
      • ELISA
      • Radioimmunoassay
      Application NotesWestern blotting

      Protein standard

      ELISA

      Radioimmunoassay

      Optimal working dilution must be determined by the end user.
      Biological Information
      Concentration1 mg/mL
      PurityContains >99% pure GFAP, a 50 kDa single band by SDS-PAGE.
      Entrez Gene Number
      Gene Symbol
      • GFAP
      • FLJ45472
      UniProt Number
      Molecular Weight49.44 kDa (428 a.a. spliced isoform; NP_001231326) and 53.63 kDa (468 a.a. spliced isoform; XP_005668766) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C to -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

      During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      GLIAL FIBRILLARY ACIDIC PROTEIN 2470349
      GLIAL FIBRILLARY ACIDIC PROTEIN, PORCINE PURIFIED PROTEIN - 2381733 2381733
      GLIAL FIBRILLARY ACIDIC PROTEIN, PORCINE PURIFIED PROTEIN - 2383055 2383055
      GLIAL FIBRILLARY ACIDIC PROTEIN, PORCINE PURIFIED PROTEIN - 2004517 2004517
      GLIAL FIBRILLARY ACIDIC PROTEIN, PORCINE -2526730 2526730
      GLIAL FIBRILLARY ACIDIC PROTEIN, PORCINE -2642658 2642658
      GLIAL FIBRILLARY ACIDIC PROTEIN, PORCINE -2661323 2661323
      GLIAL FIBRILLARY ACIDIC PROTEIN, PORCINE -2728346 2728346
      GLIAL FIBRILLARY ACIDIC PROTEIN, PORCINE -2736445 2736445
      GLIAL FIBRILLARY ACIDIC PROTEIN, PORCINE PURIFIED PROTEIN - 2287113 2287113

      References

      Reference overviewPub Med ID
      Heterogeneous intrastriatal pattern of proteins regulating axon growth in normal adult human brain.
      Tong, J; Furukawa, Y; Sherwin, A; Hornykiewicz, O; Kish, SJ
      Neurobiology of disease  41  458-68  2011

      Show Abstract
      21029775 21029775
      Photostimulated expression of type 2 iodothyronine deiodinase mRNA is greatly attenuated in the rostral tuberal hypothalamus of the photorefractory turkey hen.
      M Q Steinman,S C Dinius,T D Siopes,J R Millam
      Journal of neuroendocrinology  20  2008

      Show Abstract
      18752654 18752654

      Data Sheet

      Title
      Glial Fibrillary Acidic Protein, porcine - Data Sheet