14-679M | HIPK1 Protein, active, 250 µg

14-679M
250 µg  Also available in 10 μg size (cat#14-679) and in bulk (cat#14-679-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-679M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionHIPK1 Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant, human HIPK1, amino acids 158-555.
      References
      Product Information
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, human HIPK1, amino acids 158-555. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHIPK1 expressed by baculovirus in Sf21 cells.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
      Gene Symbol
      • HIPK1
      • MGC33446
      • KIAA0630
      • Nbak2
      • MGC26642
      • MGC33548
      • Myak
      Protein TargetHIPK1
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyCMGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q86Z02 # May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation.
      SIZE: 1210 amino acids; 130843 Da
      SUBUNIT: Interacts with Nkx1-2 and Nkx2-5 (By similarity). Interacts with DAXX and TP53.
      SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear.
      TISSUE SPECIFICITY: Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines.
      PTM: Autophosphorylated. Phosphorylated and activated by JNK1.
      SIMILARITY: SwissProt: Q86Z02 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. & Contains 1 protein kinase domain.
      Molecular Weight49.6kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of MBP (13-104).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-679) and in bulk (cat#14-679-K).
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-679 HIPK1 Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases