385880 | Hsp25 Kinase Inhibitor - Calbiochem

385880
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₆₁H₁₁₃N₂₁O₁₆

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      385880-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase [also called mitogen-activated protein kinase-activated protein kinase-2 (MAPKAP kinase-2)]. Inhibition is competitive with respect to the substrate peptide (Ki = 8.1 µM) and non-competitive with respect to ATP (Ki = 134 µM).
          Catalogue Number385880
          Brand Family Calbiochem®
          SynonymsMK2 Inhibitor, KKKALNRQLGVAA, MAPKAP Kinase-2 Inhibitor
          References
          ReferencesKatsoulidis, E., et al. 2005. Cancer Res. 65, 9029.
          Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₆₁H₁₁₃N₂₁O₁₆
          Chemical formulaC₆₁H₁₁₃N₂₁O₁₆
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary Target(Hsp25) kinase
          Primary Target K<sub>i</sub>8.1 µM against (Hsp25) kinase
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceH-Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          385880

          References

          Reference overview
          Katsoulidis, E., et al. 2005. Cancer Res. 65, 9029.
          Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.

          Brochure

          Title
          MAP Kinases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-March-2009 JSW
          SynonymsMK2 Inhibitor, KKKALNRQLGVAA, MAPKAP Kinase-2 Inhibitor
          DescriptionA 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase. Inhibits Hsp25 kinase competitively with respect to the substrate peptide (Ki = 8.1 µM) and non-competitive with respect to ATP (Ki = 134 µM). [Hsp 25 kinase is also called mitogen-activated protein kinase-activated protein kinase-2 (MK2).]
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Chemical formulaC₆₁H₁₁₃N₂₁O₁₆
          Peptide SequenceH-Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH
          Purity≥98% by HPLC
          SolubilityDMSO or H₂O
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
          Toxicity Standard Handling
          ReferencesKatsoulidis, E., et al. 2005. Cancer Res. 65, 9029.
          Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.