01-142 | IGF-II, insulin-like growth factors II

01-142
25 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesSource
      CULTHumanRecombinant DNA expressed in E. coli.
      Description
      Catalogue Number01-142
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionIGF-II, insulin-like growth factors II
      References
      Product Information
      Presentationlypholized from 0.1M acetic acid solution
      Applications
      Application25 µg of IGF-II, insulin-like growth factors II.
      Key Applications
      • Cell Culture
      Biological Information
      SourceRecombinant DNA expressed in E. coli.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the insulin family of polypeptide growth factors that is involved in development and growth. It is an imprinted gene and is expressed only from the paternally inherited allele. It is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3' region and to the upstream INS gene at the 5' region. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
      Gene Symbol
      • IGF2
      • FLJ22066
      • FLJ44734
      • pp9974
      • IGF-II
      • ORFNames=PP1446
      • INSIGF
      • C11orf43
      Purification MethodSterilized through a 0.2 micron membrane filter
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01344 # The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
      SIZE: 180 amino acids; 20140 Da
      SUBCELLULAR LOCATION: Secreted.
      SIMILARITY: SwissProt: P01344 ## Belongs to the insulin family.
      Stem Cell Type
      • Neural Stem Cells
      • Epithelial Cells
      • Mesenchymal Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated in an ATP endpoint assay
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      IGF-II - 1350256 1350256
      IGF-II - 15906 15906
      IGF-II - 29618 29618
      IGF-II - JBC1883065 JBC1883065
      IGF-II -2697387 2697387

      References

      Reference overviewPub Med ID
      Insulin-like growth factors.
      LeRoith, D and Roberts, C T
      Ann. N. Y. Acad. Sci., 692: 1-9 (1993)  1993

      Show Abstract
      8215015 8215015
      Structure and activity dependence of recombinant human insulin-like growth factor II on disulfide bond pairing.
      Smith, M C, et al.
      J. Biol. Chem., 264: 9314-21 (1989)  1989

      Show Abstract
      2722836 2722836

      Data Sheet

      Title
      Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors