14-684M | IRAK1 Protein, active, 250 µg

14-684M
250 µg  Also available in 10 μg size (cat#14-684) and in bulk (cat# 14-684-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-684M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionIRAK1 Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant, human IRAK1 amino acids 194-end.
      References
      Product Information
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, human IRAK1 amino acids 194-end. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman IRAK1 expressed by baculovirus in Sf21 cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • IRAK1
      • IRAK
      • IRAK-1
      • pelle
      Protein TargetIRAK1
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTKL
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51617 # Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.
      COFACTOR: Magnesium.
      SIZE: 712 amino acids; 76537 Da
      SUBUNIT: IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1.
      TISSUE SPECIFICITY: Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.
      PTM: Autophosphorylated or is transphosphorylated by IRAK4 following recruitment to the IL-1RI. In the case of isoform 1, this is linked to ubiquitination and degradation.
      SIMILARITY: SwissProt: P51617 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 protein kinase domain.
      Molecular Weight59.7kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of MBP (13-104).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-684) and in bulk (cat# 14-684-K).
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-684 IRAK1 Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases