14-634M | MuSK Protein, active, 250 µg

14-634M
250 µg  Also available in 10 μg size (cat#14-634) and in bulk (cat#14-634-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-634M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionMuSK Protein, active, 250 µg
      OverviewN-terminal His6-tagged, recombinant, human MuSK
      References
      Product Information
      Applications
      ApplicationActive, N-terminal His6-tagged, recombinant, human MuSK, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourcehuman MuSK, amino acids 530-end, expressed by baculovirus in Sf21 cells
      Entrez Gene Number
      Entrez Gene SummaryIntercellular communication is often mediated by receptors on the surface of one cell that recognize and are activated by specific protein ligands released by other cells. Members of one class of cell surface receptors, receptor tyrosine kinases (RTKs), are characterized by having a cytoplasmic domain containing intrinsic tyrosine kinase activity. This kinase activity is regulated by the binding of a cognate ligand to the extracellular portion of the receptor. DeChiara et al. (1996) [PubMed 8653786] noted that the RTKs, known to be expressed in cell type-specific fashions, play a role critical for the growth and differentiation of those cell types. For example, members of the neural-specific TRK family that recognize nerve growth factor are absolutely required for the survival and development of discrete neuronal subpopulations, and the receptor tyrosine kinases TIE1 (MIM 600222) and TIE2 (MIM 600221) play a critical role in the development of normal blood vessels.[supplied by OMIM]
      Gene Symbol
      • MUSK
      • MuSK
      • MGC126323
      • MGC126324
      Protein TargetMuSK
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O15146 # Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization (By similarity).
      SIZE: 869 amino acids; 97056 Da
      SUBUNIT: Interacts with DOK7, which probably regulates its activity (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
      DISEASE: SwissProt: O15146 # Defects in MUSK is a cause of autosomal recessive congenital myasthenic syndrome (CMS) [MIM:608931]. Congenital myasthenic syndromes are inherited disorders of neuromuscular transmission that stem from mutations in presynaptic, synaptic, or postsynaptic proteins. MUSK mutations lead to decreased agrin- dependent AChR aggregation, a critical step in the formation of the neuromuscular junction.
      SIMILARITY: SwissProt: O15146 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 1 FZ (frizzled) domain. & Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular Weight43.1kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of MBP (13-104)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-634) and in bulk (cat#14-634-K).
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-634 MuSK Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases