17-499 | Phosphorylation Explorer Pack Sample Kit

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      Replacement Information
      Catalogue Number17-499
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPhosphorylation Explorer Pack Sample Kit
      Background Information4G10® Platinum
      The development of the anti-phosphotyrosine, clone 4G10® in 1989 was a monumental discovery for researchers. 4G10® was the first and is the best single monoclonal antibody for the detection tyrosine phosphorylation. 4G10® is well known for its sensitivity and its ability to detect multiple tyrosine phosphorylations on numerous substrates. It has been validated by thousands of scientific and medical researchers in virtually every application and tyrosine target over the past 2 decades. To improve on something that hundred have tried and no one has succeeded, we pooled 4G10® with the next most highly regarded anti-phosphotyrosine, clone PY20 to make 4G10® Platinum. PY20 itself is a very poor substitute for 4G10®, but its additive effect allow for a greater level of detection on more substrates that even 4G10® alone was not capable of.

      The identification of protein phosphorylation as a regulatory mechanism originated from studies by Fischer and Krebs in the mid 1950s that later earned them the 1992 Nobel prize. It is the major mechanism for the regulation of diverse cellular processes including cell division, protein synthesis, transcriptional regulation and neurotransmission. The steady state phosphorylation of any given substrate is governed by the opposing activities of kinases and phosphatases. It is now believed that a third of all eukaryotic cellular proteins are phosphorylated and that the majority of all phosphorylation events occur on serine and threonine residues (greater than 95%).
      Product Information
      • This product contains the following components:
      • Cat. # 05-1050X 4G10® Platinum, Anti-phosphotyrosine
      • Cat. # 05-1000X Anti-Phosphoserine, Clone 4A4
      • Click above links for formulation, storage/handling conditions and product specific images and certificates of analysis.
      ApplicationThis Antibody pack contains Anti-phosphotyrosine Antibody, Anti-Phosphoserine Antibody, validated for use in WB, IF, Flow, IHC, ELISA, ICC.
      Key Applications
      • Western Blotting
      • Immunofluorescence
      • Flow Cytometry
      • Immunohistochemistry
      • ELISA
      • Immunocytochemistry
      Biological Information
      Clone4G10® Platinum and 4A4
      • Phosphorylation
      Molecular WeightDependent upon the molecular weight of the tyrosine phosphorylated protein being detected.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsSee individual components for storage/handling conditions.
      Packaging Information
      Material Size1 kit
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Antibody Kits