14-527 | Ros Protein, active, 10 µg

14-527
10 µg  Also available in 250 µg size --call for pricing and availability and reference catalog number 14-527M when ordering the 250 µg size.
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      Overview

      Replacement Information
      Description
      Catalogue Number14-527
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionRos Protein, active, 10 µg
      OverviewN-terminal His6-tagged recombinant human Ros residues 1883-end
      References
      Product Information
      Applications
      ApplicationActive, N-terminal His6-tagged recombinant human Ros residues 1883-end, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.
      Gene Symbol
      • ROS1
      • MCF3
      • ROS
      • OTTHUMP00000040389
      Protein TargetRos
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08922 # This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.
      SIZE: 2347 amino acids; 263915 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DISEASE: SwissProt: P08922 # A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM). An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
      SIMILARITY: SwissProt: P08922 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 9 fibronectin type-III domains. & Contains 1 protein kinase domain.
      Molecular Weight53.4kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of KKKSPGEYVNIEFG
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250 µg size --call for pricing and availability and reference catalog number 14-527M when ordering the 250 µg size.
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-527M Ros Protein, active, 250 µg Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases
      Life Science Research > Proteins and Enzymes > Purified Kinases