23-024M | p27 Protein complex, activated, 250 µg

250 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service


      Contact Customer Service

      Click To Print This Page


      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesCascade Component
      Catalogue Number23-024M
      Brand Family Upstate
      Trade Name
      • Upstate
      Descriptionp27 Protein complex, activated, 250 µg
      OverviewAXIS Axon Isolation Devices, 500 µm long channels, 10 devices
      Alternate Names
      • p27kip1
      • Cyclin-dependent kinase inhibitor 1B
      • Kip1
      Background Informationp27 is an important regulator of cell cycle progression, involved in G1 arrest. It is a potent inhibitor of cyclin E1- and cyclin A-CDK2 complexes and a positive regulator of cyclin D-dependent kinases such as CDK4. The degradation of this protein, which is triggered by its CDK-dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Decreased levels of p27 are found in various epithelial tumours originating from lung, breast, colon, ovary, oesophagus, thyroid and prostate. Defects in the gene encoding p27 (CDKN1B) are the cause of multiple endocrine neoplasia type 4 (MEN4) an inherited cancer of the thyroid.
      Product Information
      ApplicationActivated complex of three full length, recombinant human proteins: p27, Cyclin E1 & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays.
      Key Applications
      • Enzyme Assay
      Biological Information
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Cascade ComponentSubstrate
      Entrez Gene Number
      Purification MethodPurified using immobilized metal affinity chromatography.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      23-024 p27 Protein complex, activated, 10 µg Show Pricing & Availability

      Product Families


      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Ubiquitination Substrates
      Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitination Substrates