171591 β-Amyloid Peptide (1-40), Human, Fluorescent-Labeled

171591
  
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      Overview

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      This product has been discontinued.





      An N-terminally modified human Aβ1-40 peptide labeled with a fluorophore, 7-diethylaminocoumarin-3-carbonyl (DAC) that shares a common binding site with Aβ1-40 (Cat. No. 171590) with 40-fold greater affinity. Displays stronger affinity towards GM1-ganglioside and cholesterol containing membranes but little affinity for phospholipids. Exhibits only a weak fluorescence in aqueous medium; however, it strongly fluoresces upon binding to membranes. Useful in assessing the binding affinity of Aβ for various membranes.
      Catalogue Number171591
      Brand Family Calbiochem®
      SynonymsDAC-Aβ1-40, Human
      References
      ReferencesKakio, A., et al. 2002. Biochemistry 41, 7385.
      Kakio, A., et al. 2001. J. Biol. Chem. 276, 24985.
      Mizuno, T., et al. 1999. J. Biol. Chem. 274, 15110.
      Product Information
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₂₀₈H₃₀₈N₅₄O₆₁S
      Chemical formulaC₂₀₈H₃₀₈N₅₄O₆₁S
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Emission max.
      Excitation max.
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -70°C. Stock solutions are stable for up to 1 month at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      171591

      References

      Reference overview
      Kakio, A., et al. 2002. Biochemistry 41, 7385.
      Kakio, A., et al. 2001. J. Biol. Chem. 276, 24985.
      Mizuno, T., et al. 1999. J. Biol. Chem. 274, 15110.

      Brochure

      Title
      Alzheimer's Disease Brochure & Technical Guide
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-April-2008 RFH
      SynonymsDAC-Aβ1-40, Human
      DescriptionAn N-terminally modified human Aβ1-40 peptide labeled with a fluorophore, 7-diethylaminocoumarin-3-carbonyl (DAC), which shares a common binding site with Aβ1-40 (Cat. No. 171590). However, it displays about 40-fold greater affinity than Aβ1-40. Exhibits only a weak fluorescence in aqueous medium; however, it fluoresces strongly upon binding to the membranes. Displays greater affinity towards the GM1-ganglioside and cholesterol-containing membranes but little affinity for phospholipids. A reduction in GM1 content is reported to reduce DAC-Aβ1-40 binding to membranes. DAC fluorescence can be used to assess the binding affinity of Aβ for various membranes. Excitation max.: ~430 nm; emission max.: ~470 nm.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀₈H₃₀₈N₅₄O₆₁S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Solubility25% Acetic Acid (1 mg/ml) or DMSO (5 mg/ml)
      Storage ≤ -70°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -70°C. Stock solutions are stable for up to 1 month at -70°C.
      Toxicity Standard Handling
      ReferencesKakio, A., et al. 2002. Biochemistry 41, 7385.
      Kakio, A., et al. 2001. J. Biol. Chem. 276, 24985.
      Mizuno, T., et al. 1999. J. Biol. Chem. 274, 15110.