119139 Adenosine A₃ Receptor Agonist, 2-Cl-IB-MECA - CAS 163042-96-4 - Calbiochem

A highly selective agonist of adenosine A3 receptor (Ki = 330 pM)

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Cl-IB-MECA, 2-chloro-IB-MECA

119139
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₈H₁₈ClIN₆O₄163042-96-4

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      119139-2MG
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          		 Glass bottle 2 mg
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          Description
          OverviewAn adenosine analog that acts as a highly selective agonist of adenosine A3 receptor (Ki = 330 pM, 820 nM, 470 nM for A3, A1 and A2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.
          Catalogue Number119139
          Brand Family Calbiochem®
          Synonyms2-Cl-IB-MECA, 2-chloro-IB-MECA
          References
          ReferencesKim, H. O., et al. 1994. J Med Chem. 37, 3614.
          Laudadio, M. A., et al. 2004. Epilepsy Res. 59, 83.
          Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther. 319, 1200.
          Product Information
          CAS number163042-96-4
          FormWhite solid
          Hill FormulaC₁₈H₁₈ClIN₆O₄
          Chemical formulaC₁₈H₁₈ClIN₆O₄
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          119139

          References

          Reference overview
          Kim, H. O., et al. 1994. J Med Chem. 37, 3614.
          Laudadio, M. A., et al. 2004. Epilepsy Res. 59, 83.
          Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther. 319, 1200.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2014 JSW
          Synonyms2-Cl-IB-MECA, 2-chloro-IB-MECA
          DescriptionAn adenosine analog that acts as a highly selective agonist of adenosine A3 receptor (Ki = 330 pM, 820 nM, 470 nM for A3, A1 and A2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number163042-96-4
          Chemical formulaC₁₈H₁₈ClIN₆O₄
          Purity≥98% by HPLC
          SolubilityDMSO (20 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKim, H. O., et al. 1994. J Med Chem. 37, 3614.
          Laudadio, M. A., et al. 2004. Epilepsy Res. 59, 83.
          Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther. 319, 1200.