119117 Anti-A1 Adenosine Receptor (309-326) Rabbit pAb

119117
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes the ~36-40 kDa G-protein-coupled A1AR in human and rat brain, spinal cord, white adipocytes, kidney, and testis.
    • Antibody Target Gene Symbol: ADORA1
    • Target Synonym: A1 ADENOSINE RECEPTOR, A1-AR, A1R, AA1R, Ad1, ADENOSINE A1 RECEPTOR, AI848715, BB176431, RDC7, Ri
    • Entrez Gene Name: adenosine A1 receptor
    • Hu Entrez ID: 134 (Related Antibodies: PC158)
    • Mu Entrez ID: 11539
    • Rat Entrez ID: 29290
    • Catalogue Number119117
      Brand Family Calbiochem®
      SynonymsAnti-A1AR
      References
      ReferencesJohnston, J.B., et al. 2001. Annu. Neurol. 49(5), 650.
      Olah, M.E., and Stiles, G.L. 2000. Pharmacol. Ther. 85(2), 55.
      Product Information
      FormLiquid
      FormulationIn PBS, 1 mg/ml BSA.
      Positive controlHuman and rat brain, spinal cord, white adipocytes, kidney or testis
      Preservative≤ 0.1% sodium azide
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Immunohistochemistry
      Immunoprecipitation
      Application NotesImmunoblotting (1:1,000)
      Immunohistochemistry (1:100)
      Immunoprecipitation (see comments)
      Application CommentsWeakly cross-reacts with bovine A1AR in immunoblots. This antibody is also reported to work for immunoprecipitation. Variables associated with assay conditions will dictate the optimal working dilution.
      Biological Information
      Immunogena synthetic peptide (CQPKPPIDEDLPEEKAED) corresponding to amino acids 309-326 of rat adenosine receptor subtype A1 (A1AR)
      ImmunogenRat
      HostRabbit
      IsotypeIgG
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      119117

      References

      Reference overview
      Johnston, J.B., et al. 2001. Annu. Neurol. 49(5), 650.
      Olah, M.E., and Stiles, G.L. 2000. Pharmacol. Ther. 85(2), 55.

      Brochure

      Title
      Antibody Sourcebookル Sixth Edition
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2007 RFH
      SynonymsAnti-A1AR
      ApplicationImmunoblotting (1:1,000)
      Immunohistochemistry (1:100)
      Immunoprecipitation (see comments)
      DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the 36-40 kDa A1AR protein.
      BackgroundAdenosine produces a wide variety of physiological effects through the activation of cell surface adenosine receptors (ARs). ARs are members of the G-protein-coupled receptor family, and currently, four subtypes, the A1AR, A2AAR, A2BAR, and A3AR, are recognized. The A1AR is a glycoprotein (36-40 kDa) that can activate Gi and Go proteins in vitro. A1AR is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release. It has been reported that adenosine A1 receptor (A1AR) regulates tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6) expression and exhibits diminished function in patients with multiple sclerosis. Other tissues also express A1AR, including kidney and testis.
      HostRabbit
      Immunogen speciesRat
      Immunogena synthetic peptide (CQPKPPIDEDLPEEKAED) corresponding to amino acids 309-326 of rat adenosine receptor subtype A1 (A1AR)
      IsotypeIgG
      Speciesbovine (weakly), human, rat
      Positive controlHuman and rat brain, spinal cord, white adipocytes, kidney or testis
      FormLiquid
      FormulationIn PBS, 1 mg/ml BSA.
      Preservative≤ 0.1% sodium azide
      CommentsWeakly cross-reacts with bovine A1AR in immunoblots. This antibody is also reported to work for immunoprecipitation. Variables associated with assay conditions will dictate the optimal working dilution.
      Storage -20°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesJohnston, J.B., et al. 2001. Annu. Neurol. 49(5), 650.
      Olah, M.E., and Stiles, G.L. 2000. Pharmacol. Ther. 85(2), 55.