178489 Apoptosis Inducer Set II

178489
  
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      Overview

      Replacement Information

      Key Spec Table

      Description
      Overview

      This product has been discontinued.





      This set contains six ready-to-use chemical reagents that induce apoptosis through different mechanisms. The set contains 100 µl DMSO solutions each of Aphidicolin (10 µg/µl; Cat. No. 178273); Betulinic Acid (20 µg/µl; Cat. No. 200498); Paclitaxel, Taxus brevifolia (2 µg/µl; Cat. No. 580555); Staurosporine, Streptomyces sp. (0.5 µg/µl; Cat. No. 569397); and 100 µl aqueous solutions of Doxorubicin, Hydrochloride (5 µg/µl, Cat. No. 324380); and Puromycin, Dihydrochloride (20 µg/µl; Cat. No. 540222). Recommended dilution for use: 1:1000. Supplied with a data sheet.
      Catalogue Number178489
      Brand Family Calbiochem®
      References
      ReferencesLing, Y., et al. 2001. ol Pharmacol. 59, 593.
      Yang, X.H, et al. 2001. Cancer Res. 61, 348.
      Sanwal, V., et al. 2001. Exp. Mol. Pathol. 70, 54.
      Fulda, S., and Debatin, K.M. 2000. Med. Pediatr. Oncol. 35, 616.
      Shim, Y.H., et al. 2000. Int. J. Hematol. 72, 484.
      Sangfelt, O., et al. 1997. Cell Growth Differ. 8, 343.
      Product Information
      FormLiquid
      Formulation100 µl each inhibitor in DMSO or H₂O
      Applications
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38-41-45-46-60

      Irritating to eyes, respiratory system and skin.
      Risk of serious damage to eyes.
      May cause cancer.
      May cause heritable genetic damage.
      May impair fertility.
      S PhraseS: 26-36/37/39-45-53-28

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Multiple Toxicity Values, refer to MSDS
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot, purge with inert gas, and freeze (-20°C). Once opened, stock solutions are stable for up to 3 months when stored under the indicated conditions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      178489

      References

      Reference overview
      Ling, Y., et al. 2001. ol Pharmacol. 59, 593.
      Yang, X.H, et al. 2001. Cancer Res. 61, 348.
      Sanwal, V., et al. 2001. Exp. Mol. Pathol. 70, 54.
      Fulda, S., and Debatin, K.M. 2000. Med. Pediatr. Oncol. 35, 616.
      Shim, Y.H., et al. 2000. Int. J. Hematol. 72, 484.
      Sangfelt, O., et al. 1997. Cell Growth Differ. 8, 343.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-August-2008 RFH
      DescriptionContains 6 ready-to-use chemical reagents that induce apoptosis through different mechanisms. Aphidicolin, is a specific inhibitor of DNA polymerase α and δ. Betulinic Acid is an antitumor and anti-HIV agent. Paclitaxel, Taxus brevifolia is an antitumor and antileukemic agent. Staurosporine, Streptomyces sp. is a potent, cell-permeable, and broad spectrum inhibitor of protein kinases that also induces apoptosis. Doxorubicin, Hydrochloride is an antitumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II. Puromycin, Dihydrochloride is a nucleotide that resembles the aminoacyl-adenyl terminus of aminoacyl-tRNA and competes for binding to the large ribosomal subunit, which causes termination. A dilution of 1:1000 is recommended for inducing apoptosis in most cell types, but the optimal dose may vary for different cell types and culture conditions; please consult published literature to determine optimal dilution and incubation time for individual samples. Set contains 100 µl each of the following components:

      Components
      • Aphidicolin (Cat. No. KS13301-100UL), (10 µg/µl in DMSO)
      • Betulinic Acid (Cat. No. KS13302-100UL), (20 µg/µl in DMSO)
      • Paclitaxel, Taxus brevifolia (Cat. No. KS13303-100UL), (2 µg/µl in DMSO)
      • Staurosporine, Streptomyces sp. (Cat. No. KS13304-100UL), (0.5 µg/µl in DMSO)
      • Doxorubicin, Hydrochloride (Cat. No. KS13305-100UL), (5 µg/µl in H2O)
      • Puromycin, Dihydrochloride (Cat. No. KS13306-100UL), (20 µg/µl in H2O)
      FormLiquid
      Formulation100 µl each inhibitor in DMSO or H₂O
      Intert gas (Yes/No) Packaged under inert gas
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot, purge with inert gas, and freeze (-20°C). Once opened, stock solutions are stable for up to 3 months when stored under the indicated conditions.
      Toxicity Multiple Toxicity Values, refer to MSDS
      ReferencesLing, Y., et al. 2001. ol Pharmacol. 59, 593.
      Yang, X.H, et al. 2001. Cancer Res. 61, 348.
      Sanwal, V., et al. 2001. Exp. Mol. Pathol. 70, 54.
      Fulda, S., and Debatin, K.M. 2000. Med. Pediatr. Oncol. 35, 616.
      Shim, Y.H., et al. 2000. Int. J. Hematol. 72, 484.
      Sangfelt, O., et al. 1997. Cell Growth Differ. 8, 343.