182015 Cyclo(Arg-Gly-Asp-D-Phe-Val) - CAS 137813-35-5 - Calbiochem

Potent inhibitor of cell adhesion.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: RGDFV Peptide, Cyclic

Primary Target: inhibits tumor cell adhesion to laminin and vitronectin substrates
182015
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₆H₃₈N₈O₇137813-35-5

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      182015-1MG
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          		 Plastic ampoule 1 mg
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          Description
          OverviewPotent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.
          Catalogue Number182015
          Brand Family Calbiochem®
          SynonymsRGDFV Peptide, Cyclic
          References
          ReferencesShono, T., et al. 2001. Exp. Cell Res. 268, 169.
          Matsuno, H., et al. 1994. Circulation 90, 2203.
          Noiri, E., et al. 1994. Kidney Int. 46, 1050.
          Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.
          Product Information
          CAS number137813-35-5
          ATP CompetitiveN
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt
          Hill FormulaC₂₆H₃₈N₈O₇
          Chemical formulaC₂₆H₃₈N₈O₇
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          182015

          References

          Reference overview
          Shono, T., et al. 2001. Exp. Cell Res. 268, 169.
          Matsuno, H., et al. 1994. Circulation 90, 2203.
          Noiri, E., et al. 1994. Kidney Int. 46, 1050.
          Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-April-2008 RFH
          SynonymsRGDFV Peptide, Cyclic
          DescriptionPotent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion.
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt
          CAS number137813-35-5
          Chemical formulaC₂₆H₃₈N₈O₇
          Purity≥95% by HPLC
          Solubility1 N Acetic acid (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesShono, T., et al. 2001. Exp. Cell Res. 268, 169.
          Matsuno, H., et al. 1994. Circulation 90, 2203.
          Noiri, E., et al. 1994. Kidney Int. 46, 1050.
          Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.