AB5042P Anti-Choline Acetyltransferase Antibody

20 µg  
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      Tabela kluczowych gatunków

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R ELISA, IHC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberAB5042P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Choline Acetyltransferase Antibody
      Alternate Names
      • ChAT
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Lyophilized. Contains no preservative. Reconstitute with 20 μL of sterile distilled water. Centrifure to remove any insoluble material.
      ApplicationDetect Choline Acetyltransferase using this Anti-Choline Acetyltransferase Antibody validated for use in ELISA, IH.
      Key Applications
      • ELISA
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:2,000-1:4,000 in rat basal forebrain.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA 22 amino acid synthetic peptide from porcine ChAT, coupled to KLH. The peptide sequence is GLFSSYRLPGHTQDTLVAQKSS. Due to sequence similarity, the antibody is expected to react with pig, mouse primate and human ChAT.
      SpecificityCholine acetyltranferase. The antibody will stain cholinergic neurons in the rat central and peripheral nervous systems.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein.
      Gene Symbol
      • CHAT
      • ChAT
      • CMS1A2
      • CHOACTase
      • CMS1A
      • EC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P28329 # Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
      SIZE: 748 amino acids; 82568 Da
      DISEASE: SwissProt: P28329 # Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.
      SIMILARITY: SwissProt: P28329 ## Belongs to the carnitine/choline acetyltransferase family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material dry at -70°C for up to 12 months after date of receipt. After reconstitution, maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
      Packaging Information
      Material Size20 µg
      Transport Information
      Supplemental Information


      Anti-Choline Acetyltransferase Antibody MSDS


      Safety Data Sheet (SDS) 

      Anti-Choline Acetyltransferase Antibody Certificates of Analysis

      TitleLot Number


      Reference overviewPub Med ID
      Neural pathways associated with loss of consciousness caused by intracerebral microinjection of GABA A-active anesthetics.
      I Sukhotinsky, V Zalkind, J Lu, D A Hopkins, C B Saper, M Devor, I Sukhotinsky, V Zalkind, J Lu, D A Hopkins, C B Saper, M Devor
      The European journal of neuroscience  25  1417-36  2007

      Pokaż streszczenie
      17425568 17425568
      Hypoglycemia activates arousal-related neurons and increases wake time in adult rats.
      Nancy C Tkacs,Yanhua Pan,Gagan Sawhney,Graziella L Mann,Adrian R Morrison
      Physiology & behavior  91  2007

      Pokaż streszczenie Pełny tekst artykułu
      17434543 17434543
      Platelet-activating factor in the enteric nervous system of the guinea pig small intestine.
      Wang, GD; Wang, XY; Hu, HZ; Fang, XC; Liu, S; Gao, N; Xia, Y
      American journal of physiology. Gastrointestinal and liver physiology  291  G928-37  2006

      Pokaż streszczenie
      17030900 17030900
      Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity.
      Darman, J; Backovic, S; Dike, S; Maragakis, NJ; Krishnan, C; Rothstein, JD; Irani, DN; Kerr, DA
      The Journal of neuroscience : the official journal of the Society for Neuroscience  24  7566-75  2004

      Pokaż streszczenie
      15329404 15329404
      Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury.
      Douglas A Kerr, Jerònia Lladó, Michael J Shamblott, Nicholas J Maragakis, David N Irani, Thomas O Crawford, Chitra Krishnan, Sonny Dike, John D Gearhart, Jeffrey D Rothstein
      The Journal of neuroscience : the official journal of the Society for Neuroscience  23  5131-40  2003

      Pokaż streszczenie
      12832537 12832537
      Antibodies raised against synthetic peptides react with choline acetyltransferase in various immunoassays and in immunohistochemistry.
      Benecke, S, et al.
      J. Neurochem., 61: 804-11 (1993)  1993

      8360685 8360685

      Data Sheet

      Anti-Choline Acetyltransferase - Data Sheet

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      Life Science Research > Antibodies and Assays > Primary Antibodies