MAB5350 Anti-Choline Acetyltransferase Antibody, clone 28C4

MAB5350
100 µg  
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      Tabela kluczowych gatunków

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Gp, H, Mk, R ELISA, IHC, WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB5350
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Choline Acetyltransferase Antibody, clone 28C4
      Alternate Names
      • ChAT
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid.
      Applications
      ApplicationAnti-Choline Acetyltransferase Antibody, clone 28C4 detects level of Choline Acetyltransferase & has been published & validated for use in ELISA, IH & WB.
      Key Applications
      • ELISA
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blotting: 1:1,000-1:10,000 using a high sensitivity ECL kit. Recognizes a protein of ~67 kDa. May also recognize a protein of 35 kDa which is thought to be a degradation product. Suggested dilution buffer is TBS containing 5% skim milk powder and 0.05% Tween 20.

      Immunohistochemistry on free-floating frozen sections of Rhesus monkey brain fixed with 4% paraformaldehyde and coronal vibratome sections of rat brain fixed with 4% paraformaldehyde and 0.2% glutaraldehyde.

      ELISA (two side)

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPurified human placenta ChAT.
      Clone28C4
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with Choline Acetyltransferase (ChAT).
      IsotypeIgG
      Species Reactivity
      • Guinea Pig
      • Human
      • Monkey
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein.
      Gene Symbol
      • CHAT
      • ChAT
      • CMS1A2
      • CHOACTase
      • CMS1A
      • EC 2.3.1.6
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P28329 # Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
      SIZE: 748 amino acids; 82568 Da
      DISEASE: SwissProt: P28329 # Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.
      SIMILARITY: SwissProt: P28329 ## Belongs to the carnitine/choline acetyltransferase family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-CHOLINE ACETYLTRANSFERASE MONOCLONAL ANTIBODY - 23922872392287
      MOUSE ANTI-CHOLINE ACETYLTRANSFERASE MONOCLONAL ANTIBODY - 24496922449692
      MOUSE ANTI-CHOLINE ACETYLTRANSFERASE MONOCLONAL ANTIBODY - 21535642153564
      MOUSE ANTI-CHOLINE ACETYLTRANSFERASE -25214682521468
      MOUSE ANTI-CHOLINE ACETYLTRANSFERASE -27940892794089
      MOUSE ANTI-CHOLINE ACETYLTRANSFERASE MONOCLONAL ANTIBODY - 20904492090449
      MOUSE ANTI-CHOLINE ACETYLTRANSFERASE MONOCLONAL ANTIBODY - 22193502219350

      References

      Reference overviewPub Med ID
      Use of ¹¹C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer.
      Huang, Z; Rui, J; Li, X; Meng, X; Liu, Q
      Molecular medicine reports  11  3285-90  2015

      Pokaż streszczenie
      25591716 25591716
      Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism.
      Kim, JW; Seung, H; Kwon, KJ; Ko, MJ; Lee, EJ; Oh, HA; Choi, CS; Kim, KC; Gonzales, EL; You, JS; Choi, DH; Lee, J; Han, SH; Yang, SM; Cheong, JH; Shin, CY; Bahn, GH
      PloS one  9  e104927  2014

      Pokaż streszczenie
      25133713 25133713
      ELISA methods to measure cholinergic markers and nerve growth factor receptors in cortex, hippocampus, prefrontal cortex, and basal forebrain from rat brain.
      Gearhart, Debra A, et al.
      J. Neurosci. Methods, 150: 159-73 (2006)  2006

      16085318 16085318

      Data Sheet

      Title
      Anti-Choline Acetyltransferase, clone 28C4 - Data Sheet

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      Kategorie

      Life Science Research > Antibodies and Assays > Primary Antibodies