119113 Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem

119113
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      Przegląd

      Replacement Information

      Tabela kluczowych gatunków

      Empirical FormulaCAS #
      C₁₄H₁₁N₃O₂ 352341-26-5

      Ceny i dostępność

      Numer katalogowyDostępność Opakowanie Ilość/opak. Cena netto Ilość
      119113-5MG
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      Dostępny w magazynie 
      Wycofano
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          Butelka szklana 5 mg
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          Description
          OverviewA 3,5-diaryl-oxadiazole compound that acts as an inhibitor against the ATP-dependent Photuris pennsylvanica (lucPpe) and Photinus pyralis (lucPpy) luciferase activity (IC50 = 0.08 and 2.8 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme) and effectively inhibits lucPpe-based commercial luciferase-luciferin formulations (IC50 = 5, 13.5, and 12.7 µM against Promega's Kinase-Glo®, Kinase-Glo® Plus, and Kinase-Glo® Max, respectively, at a 3-fold formulation dilution and 6.77 µM ATP). Unlike Luciferase Inhibitor II (Cat. No. 119114), Luciferase Inhibitor I is noncompetitive with respect to either luciferin or ATP.
          Catalogue Number119113
          Brand Family Calbiochem®
          Synonyms2-(5-(2-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridine
          References
          ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
          Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
          Product Information
          CAS number352341-26-5
          DeclarationMarketed by Promega Corp. under the registered trademarks.
          FormOff-white solid
          Hill FormulaC₁₄H₁₁N₃O₂
          Chemical formulaC₁₄H₁₁N₃O₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          119113

          References

          Przegląd literatury
          Auld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
          Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-April-2011 RFH
          Synonyms2-(5-(2-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridine
          DescriptionA 3,5-diaryl-oxadiazole compound that acts as an inhibitor against the ATP-dependent Photuris pennsylvanica (lucPpe) and Photinus pyralis (lucPpy) luciferase activity (IC50 = 0.08 and 2.8 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme) and effectively inhibits lucPpe-based commercial luciferase-luciferin formulations (IC50 = 5, 13.5, and 12.7 µM against Promega's Kinase-Glo®, Kinase-Glo® Plus, and Kinase-Glo® Max, respectively, at a 3-fold formulation dilution and 6.77 µM ATP). Unlike Luciferase Inhibitor II (Cat. No. 119114), Luciferase Inhibitor I is noncompetitive with respect to either luciferin or ATP.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number352341-26-5
          Chemical formulaC₁₄H₁₁N₃O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml) or Ethanol (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
          Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.