100122 A3, Hydrochloride

100122
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₂H₁₃ClN₂O₂S · HCl 78957-85-4
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, reversible, and shorter alkyl chain derivative of W-7 that inhibits casein kinase I (Ki = 80 µM), casein kinase II (Ki = 5.1 µM), myosin light chain kinase (Ki = 7.4 µM), protein kinase A (Ki = 4.3 µM), protein kinase C (Ki = 47 µM), and protein kinase G (Ki = 3.8 µM).
      Catalogue Number100122
      Brand Family Calbiochem®
      SynonymsN-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide, HCl
      References
      ReferencesInagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
      Turner, E.J.H., et al. 2003. Br. J. Haematol. 120, 894.
      Product Information
      CAS number78957-85-4
      FormOff-white solid
      Hill FormulaC₁₂H₁₃ClN₂O₂S · HCl
      Chemical formulaC₁₂H₁₃ClN₂O₂S · HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetCK1
      Primary Target K<sub>i</sub>80 µM
      Secondary targetCK2 (Ki = 5.1 µM), MLCK (Ki = 7.4 µM), PKA (Ki = 4.3 µM), PKC (Ki = 47 µM), PKG (Ki = 3.8 µM)
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      100122

      References

      Reference overview
      Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
      Turner, E.J.H., et al. 2003. Br. J. Haematol. 120, 894.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      SynonymsN-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide, HCl
      DescriptionA cell-permeable, reversible, and shorter alkyl chain derivative of W-7 that inhibits casein kinase I (Ki= 80 µM), casein kinase II (Ki= 5.1 µM), myosin light chain kinase (Ki= 7.4 µM), protein kinase A (Ki= 4.3 µM), protein kinase C (Ki= 47 µM) and protein kinase G (Ki= 3.8 µM).
      FormOff-white solid
      CAS number78957-85-4
      Chemical formulaC₁₂H₁₃ClN₂O₂S · HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (25 mg/ml) or 50% Ethanol (20 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesInagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
      Turner, E.J.H., et al. 2003. Br. J. Haematol. 120, 894.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Casein Kinase (CK) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors