121790 AGL 2043

121790
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      Please refer to our complete listing of receptor tyrosine kinase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





      A cell-permeable tricyclic quinoxaline compound that acts as a potent, selective, ATP-competitive, and reversible inhibitor of type III receptor tyrosine kinases PDGFR (IC50 = 800 nM in 3T3 cells; 90 nM against purified PDGFβ-receptor), Flt3, and Kit (IC50 = 1-3 µM). A weak inhibitor of PKA, EGFR, IGF-1R, VEGFR, and Src kinases (IC50 > 30 µM). Shown to be non-toxic. Potently inhibits smooth muscle cell proliferation and balloon-induced stenosis in pig heart. Displays enhanced aqueous solubility compared with its parent compound AG 1295 (Cat. No. 658550).
      Catalogue Number121790
      Brand Family Calbiochem®
      SynonymsTyrphostin AGL 2043, 1,2-Dimethyl-6-(2-thienyl)-imidazolo[5,4-g]quinoxaline
      References
      ReferencesGazit, A., et al. 2003. Bioorg. Med. Chem. 11, 2007.
      Product Information
      CAS number22617-28-8
      FormYellow solid
      Hill FormulaC₁₅H₁₂N₄S
      Chemical formulaC₁₅H₁₂N₄S
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      121790

      References

      Reference overview
      Gazit, A., et al. 2003. Bioorg. Med. Chem. 11, 2007.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2007 JSW
      SynonymsTyrphostin AGL 2043, 1,2-Dimethyl-6-(2-thienyl)-imidazolo[5,4-g]quinoxaline
      DescriptionA cell-permeable, tricyclic quinoxaline compound that acts as a potent, selective, ATP-competitive, and reversible inhibitor of type III receptor tyrosine kinases, PDGFR (IC50 = 800 nM in 3T3 cells; 90 nM against purified PDGFβ-receptor), Flt3, and Kit (IC50 ~1-3 µM). Weakly inhibits PKA, EGFR, IGF-1R, VEGFR, and Src kinases (IC50 > 30 µM). Shown to be non-toxic. Potently inhibits smooth muscle cell proliferation and balloon-induced stenosis in porcine heart. Displays enhanced aqueous solubility compared with its parent compound, AG 1295 (Cat. No 658550).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number22617-28-8
      Chemical formulaC₁₅H₁₂N₄S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesGazit, A., et al. 2003. Bioorg. Med. Chem. 11, 2007.