116845 Adenylyl Cyclase Toxins Inhibitor

116845
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      We apologize for the inconvenience, but we do not currently have an alternative product. For related products, please refer to our complete listing of adenylate cyclase inhibitors.





      A cell-permeable quinazoline compound that mimics adenine and acts as a specific, ATP-competitive (Ki ~ 20 µM) inhibitor of EF (edema factor) and CyaA adenylyl cyclase (AC) activities (IC50 = 90 µM). Does not inhibit EF-CaM (calmodulin) interaction or mammalian AC type I, II and V activities.
      Catalogue Number116845
      Brand Family Calbiochem®
      SynonymsEthyl-5-aminopyrazolo[1,5-a]quinazoline-3-carboxylate
      References
      ReferencesSoelaiman, S., et al. 2003. J. Biol. Chem. 278, 25990.
      Product Information
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₃H₁₂N₄O₂
      Chemical formulaC₁₃H₁₂N₄O₂
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetEF (edema factor) and CyaA adenylyl cyclase (AC) activities
      Primary Target IC<sub>50</sub>90 *micro;M
      Secondary targetATP-competitive (Ki ~ 20 µM)
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      116845

      References

      Reference overview
      Soelaiman, S., et al. 2003. J. Biol. Chem. 278, 25990.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      SynonymsEthyl-5-aminopyrazolo[1,5-a]quinazoline-3-carboxylate
      DescriptionA cell-permeable quinazoline compound that mimics adenine and acts as a specific, ATP-competitive (Ki ~20 µM) inhibitor of edema factor (EF) and CyaA adenylyl cyclase (AC) (IC50 = 80 µM) activities. Does not inhibit EF-calmodulin interaction or the activities of mammalian AC types I, II, or V.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃H₁₂N₄O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSoelaiman, S., et al. 2003. J. Biol. Chem. 278, 25990.